ECEESPE2025 ePoster Presentations Adrenal and Cardiovascular Endocrinology (170 abstracts)
Non-functioning adrenal cortical adenomas: analysis of 31 cases
Yesmine Elloumi 1 , Mouna Elleuch 1 , Yasmine Abdelkafi 1 , Malek Hadrich 1 , Kouloud Boujelben 1 , Hadjkacem Faten 1 , Nadia Charfi 1 , Mouna Mnif 1 , Mohamed Abid 1 , Dhoha Ben Salah 1 & Nabila Rekik Majdoub 1
1Hedi Chaker University Hospital, Endocrinology Department, Sfax, Tunisia
JOINT1364
Background: While the non-functioning adrenal cortical adenomas do not secrete hormones, they can cause subtle, prolonged cortisol release, potentially contributing to metabolic disturbances. This highlights the need for routine screening and ongoing surveillance to manage and identify early signs of metabolic syndrome associated with this entity.
Methods: This was a retrospective and descriptive study that included 31 patients followed for non-functioning adrenal cortical adenomas in the Endocrinology Department of Hedi Chaker University Hospital in Sfax, Tunisia.
Results: The mean age of patients was 57.9 years. A female predominance was observed 60% of cases. The average BMI was 28.35 kg/m2, and 25% of patients were classified as overweight. Obesity was identified in 25% of cases, with 3% having morbid obesity. An android obesity pattern was observed in 74% of patients. The average systolic blood pressure was 145.6 mmHg, and 32% of patients had a diastolic blood pressure ≥ 85 mmHg. All patients had metabolic syndrome. The mean 11 PM cortisol level was 69 ng/ml, and no patients had pathological cortisol levels. The average post low dose dexamethasone suppression test cortisol level was 10.06 ng/ml, with no patients showing a pathological suppression test. None of the patients had elevated ACTH levels (≥ 50 pg/ml). Fasting blood glucose was pathological (≥ 6.1 mmol/l) in 64.5% of cases. Elevated triglyceride levels (≥ 1.7 mmol/l) were found in 41.9% of patients, and total cholesterol was elevated in 48.3% of patients.
Conclusion: Patients with non-functioning adrenal cortical adenomas often present with metabolic abnormalities, highlighting the importance of thorough screening and continuous monitoring to manage associated risks effectively.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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