ECEESPE2025 ePoster Presentations Pituitary, Neuroendocrinology and Puberty (220 abstracts)
Case report of ependymal pituicytoma
Mehmet Yigit 1 , Hatice Ozisik 1 , Gökçen Ünal Kocabaş 1 , Ezgi Ulas 1 , Melih Bektas 1 , Aysel Mammadyarzade 1 , Yesim Ertan 1,2 , Erkin Ozgiray 1 & Banu Sarer Yurekli 1
1Ege University, Endocrinology, İzmir, Türkiye; 2Ege University, Pathology, İzmir, Türkiye.
JOINT3691
Background: Pituitary pituicytoma is a rare, low-grade primary tumor originating from pituicytes in the neurohypophysis or infundibulum. Clinically, it presents with symptoms similar to other sellar region tumors, such as visual impairment, headache, and/or pituitary hormone deficiencies, depending on tumor size. Immunohistochemical examinations are crucial for diagnosis.
Case Presentation: A 63-year-old male patient with a history of basal cell carcinoma and squamous cell carcinoma, previously treated at another center, presented to our clinic due to visual disturbances. Pituitary MRI revealed a well-defined, lobulated, solid mass measuring 17×15×10 mm in the sella, extending to the optic chiasm and involving the infundibulum, consistent with a pituitary macroadenoma. Physical examination showed bitemporal hemianopsia without motor deficits or pathological reflexes. Preoperative laboratory tests, including liver, kidney, and thyroid function tests, as well as a complete blood count, were within normal limits. The patient had no history of regular medication use, Anterior pituitary hormone levels were appropriate for his age. The patient underwent surgery at our neurosurgery department, and histopathological examination demonstrated a diagnosis of WHO grade 1 pituicytoma, specifically an ependymal pituicytoma. Immunohistochemical staining showed positive TTF-1, Ki-67 of 1%, and negative staining for S-100, synaptophysin, GFAP, and anterior pituitary hormones. Postoperatively, the patient’s visual symptoms improved, and follow-up evaluations displayed normal anterior pituitary hormone levels with no need for additional treatment.
Conclusion: According to the World Health Organization (WHO) classification, pituicytoma is a benign grade 1 tumor of the pituitary gland. It is challenging to diagnose due to its clinical and radiological similarities to other sellar region masses. The presence of a posterior pituitary lesion on MRI may suggest pituicytoma; however, immunohistochemical analysis is essential for a definitive diagnosis. To prevent recurrence, total surgical resection of the tumor is critical.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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