Endocrine Abstracts

JOINT2651

Introduction: A pituitary adenoma is a tumour of the pituitary gland and is further classified by their size, cell type and hormone secretion. Microadenoma when the tumour is <1cm and macroadenoma >1cm. This is further classified if they are functioning (producing excess hormone) or non-functioning (no hormonal excess). Cell types include Prolactinoma, somatotroph, corticotroph, thyrotroph, and gonadotroph. In rare cases can also get malignant tumour. Around 1 in 10 people will develop pituitary adenoma in their lifetime. Treatment depends on the type of pituitary adenoma and includes medication, surgery and radiation therapy. Prolactinomas are the most common type of pituitary adenoma in the UK (40-60%) and then are non-functionating tumours.

Aim: of this study was to look at the diagnosis and surgical management of pituitary adenomas referred at Queen’s Hospital, London, UK (BHRUT–Barking, Havering and Redbridge University Hospitals NHS Trust) in 2015-2022 (7 years).

Method: Retrospective single-centre study looking at patients referred for surgical management of pituitary adenoma between 2015-2025.

Results: 55 patients were identified of which 42% female and 58% male. The age of presentation was more common in the age range of 71-80years (35%) and the least common was age range 31-40years (11%). Majority of the pituitary adenomas that underwent surgical intervention were functioning (65%), whereas 20% were non-functioning and rest compromised of malignancy or apoplexy. The most common functioning type of pituitary adenoma was gonadotroph (50%), then acromegaly 20% and least common in general was malignancy 5%. Corticotroph releasing were 15% and prolactinoma were 7.5%.

Conclusion: Our single-centre study showed that majority of pituitary adenoma referred for surgical intervention were functioning of which most common was gonadotroph and second most common was acromegaly. It is important that the hormone profile and imagining is done in a timely manner and if symptoms are worsening then to timely refer patient for surgical intervention when medical management is resolving the symptoms. This helps present complications and provides a better patient outcome. A Multidisciplinary (MDT) approach is vital and is individualised for each patient.