ECEESPE2025 ePoster Presentations Pituitary, Neuroendocrinology and Puberty (220 abstracts)
Indexes of liver steatosis and fibrosis in metabolically associated fatty liver in hypopituitarism
Dragana Miljic 1 , Mirjana Doknic 1,2 , Sandra Djurdjevic 3 , Marko Stojanovic 2,4 , Zvezdana Jemuovic 2 , Ivana Cekic 2 , Ivan Jevtic 2 , Boris Kurcubic 2 & Marina Nikolic Djurovic 4
1Medical Faculty, Belgrade University, Clinic for Endocrinology, Diabetes and Metabolic Disorders, Universitz Clinical Center of Serbia, Neuroendocrinology, Belgrade, Serbia; 2Clinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Center of Srbia, Neuroendocrinology, Belgrade, Serbia; 3Faculty of Medicine, Belgrade University, Clinic for Endocrinology, Diabetes and Metabolic Disorders, Neuroendocrinology, Belgrade, Serbia; 4Faculty of Medicine, Belgrade University, Belgrade, Serbia.
JOINT982
Aim: To investigate relationship between insulin resistance, hepatic steatosis and fibrosis in hypopituitarism.
Patients and Methods: Study included 282 hypopituitary patients (136 women and 146 men) aged 49.2±15.1 years, body mass index 27.9±5.8 kg/m2, n = 140 (49.6%) due to non-functioning pituitary adenoma.
Results: Fatty liver on ultrasound was obesrved in 20.6% (n = 58). The metabolic syndrome (MetS), defined by IDF criteria, was present in 57.1% (n = 161) and 48.6% (n = 137) using NCEP ATP III. The LAP (171.8±150.1 vs 54.6±39.4, P <0.001) and FLI (15.7±15.5 vs 4.9±9.8, P <0.001) were significantly higher in patients with hypopituitarism and fatty liver, compared to those with hypopituitarism alone., while fibrosis scores FIB4 and BARD were not significiantly different between the two groups. Signifficant corellations were found between fatty liver disease, MetS and steatosis indexes LAP and FLI (P <0.001), but not with fibrosis indexes BARD and FIB4. HOMA IR and Matsuda index were siginificantly higher in patients with fatty liver compared to those with hypopituitarism alone and highly correlated with fatty liver findings on ultra sound, and steatosis indexes LAP and FLI (P <0.001), but not with indexes of liver fibrosis BARD i FIB4.
| Fatty liver | P value | |||||||
| N | Mean | SD | Median | Perc. 25 | Perc. 75 | |||
| FIB4 | No | 111 | 1.24 | .87 | 1.10 | .70 | 1.50 | 0.327 |
| Yes | 41 | 1.25 | .56 | 1.20 | .90 | 1.60 | ||
| BARD score | No | 109 | 2.28 | .89 | 2.00 | 2.00 | 3.00 | 0.732 |
| Yes | 37 | 2.35 | 1.06 | 2.00 | 2.00 | 3.00 | ||
| LAP | No | 79 | 54.58 | 39.41 | 46.50 | 25.40 | 71.40 | <0.001 |
| Yes | 32 | 171.78 | 150.17 | 122.55 | 87.57 | 203.05 | ||
| FLI | No | 64 | 4.87 | 9.85 | 1.17 | .60 | 4.05 | <0.001 |
| Yes | 29 | 15.71 | 15.46 | 10.05 | 2.70 | 24.70 |
Conclusion: Indexes of fatty liver correlated with insulin resistance and ultrasound finding of fatty liver in patients with hypopituitarism, while no such correlation was observed with indexes of liver fibrosis. Liver steatosis but not fibrosis is fueled by insulin resistance and metabolic syndrome in patients with hypopituitarism.
Volume 110
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2025 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more