Endocrine Abstracts

JOINT1826

Purpose: The potential of height growth is decreased to about 2-2.5cm after menarche and many children and their parents worry about the early menarche. This study is to find out the markers to predict the onset of menarche.

Method: We collected the anthropometric data (height, weight, and growth velocity), chronologic and bone age, Tanner stage, biochemical data (serum LH, FSH, estradiol, and progesterone levels) at 12 months and 6 months before the onset of menarche in 28 girls who visited the growth clinic of a university hospital from Jan 1, 2020 to Jul 31, 2024. The data of 12 months and 6 months were compared with the paired T-test using SPSS ver.28.

Result: The comparison of the data between the 12 months and 6 months before menarche were as follows. The mean growth velocities of height were 2.94cm and 2.92cm, and weight were 1.48kg and 2.03kg (P=NS). The bone ages were 12.5 and 12.79 years old (P=NS). The Tanner stages were almost 4 in both. The serum levels of LH were 2.34±1.38 and 4.06±2.53 mIU/ml (P <0.01). The serum levels of FSH were 4.37±1.69 and 5.86±2.07 mIU/ml (P <0.05). The serum levels of estradiol were 24.52±13.39 and 45.61±19.7 pg/ml ( P <0.01). The serum levels of progesterone were 0.12±0.1 and 0.18±0.16 ng/ml (P=NS).

Conclusion: The periodic measurements of baseline serum levels of LH, FSH, and estradiol are more valuable than anthropometric data to predict the onset of menarche in girls.