ECEESPE2025 ePoster Presentations Adrenal and Cardiovascular Endocrinology (170 abstracts)
Prevalence and evolution of diabetes in cushing’s syndrome: a 31-year retrospective study
Baltagi Myriam 1 , Ibtissem Ben Nacef 1 , Sawsen Essayeh 1 , Sabrine Mekni 1 , Rihab Laamouri 1 , Khiari Karima 1 & Rojbi Imen 1
1Hospital of Charles Nicolle, Tunis, Tunisia
JOINT2254
Introduction: Cushing’s syndrome (CS) is known to induce hyperglycemia, but the long-term prevalence and evolution of diabetes in CS remain poorly understood. This study aims to evaluate the prevalence and evolution of diabetes in CS patients over a 31-year period.
Methods: A retrospective analysis was conducted on 22 patients diagnosed with CS at the Endocrinology Department of Charles Nicolle Hospital. Data collected included demographics, clinical features, cortisol levels, and diabetes status at diagnosis, treatment initiation, and follow-up.
Results: The majority of patients (68%) presented with diabetes at the time of diagnosis, with 32% showing prediabetes. Following successful treatment and remission of hypercortisolism, 70% showed significant improvement in fasting blood glucose and HbA1c levels. Notably, there was a correlation between baseline cortisol levels and glycemic control, with higher cortisol levels associated with poorer control.
Discussion: These findings underscore the significant impact of hypercortisolism on glycemic control. The improvement in glucose metabolism after cortisol suppression further highlights the importance of managing Cushing’s syndrome effectively to mitigate diabetes-related complications.
Conclusion: Cushing’s syndrome has a substantial impact on the development and progression of diabetes. Remission of hypercortisolism leads to significant improvements in glycemic control, emphasizing the need for early diagnosis and targeted treatment to reduce diabetes burden in these patients.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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