ECEESPE2025 ePoster Presentations Pituitary, Neuroendocrinology and Puberty (220 abstracts)
A rare case report of an intravascular large B-cell lymphoma causing a panhypopituitarism
Hamza Benderradji 1,2 , Ines Arib 3 , François Walasiak 1 , Arnaud Jannin 4,5 , Mélodie-Anne Karnoub 6 , Mathieu Nobile 7 , Richard Assaker 6 , Salomon Manier 3 , Christine Do Cao 1 , Marie-Christine Vantyghem 1,8 & Emilie Merlen 4
1Department of Endocrinology, Diabetology, and Metabolism, Lille University Hospital, Lille, France; 2University of Lille, CHU-Lille, Inserm U1172, Lille Neuroscience & Cognition, Lille, France; 3Department of Hematology, Lille University Hospital, Lille, France; 4Department of Endocrine and Metabolic Surgery, Lille University Hospital, Lille, France; 5CANTHER-Cancer-Heterogeneity Plasticity and Resistance to Therapies, University of Lille, UMR9020-U1277-CNRS, INSERM, CHU Lille, Lille, France; 6Department of Neurosurgery, Lille University Hospital, Lille, France., Lille, France; 7Department of Radiology, Lille University Hospital, Lille, France; 8INSERM U1190 Translational Research in Diabetes, Firendo Rare Diseases Competence Center PRISIS, (Pathologies of insulin Resistance and Insulin Sensitivity), Lille University Hospital, Lille, France
JOINT2020
A rare and aggressive form of B-cell lymphoma known as intravascular large B-cell lymphoma (IVLBCL) is characterized by the growth of large cells within the lumen of blood vessels. While previous studies have documented a wide range of symptoms caused by neoplastic cells obstructing small vessels in various organs, there is limited literature on IVLBCL cases with hypothalamic-pituitary functional impairment. Here, we present a rare case of IVLBCL that provoked hypopituitarism. A 58-year-old male patient presented with symptoms that progressively developed over several weeks, including deteriorated general condition, intermittent episodes of confusion, daily high fever, and polyuropolydipsia syndrome (5 liters per day). Laboratory investigations revealed mild hypernatremia (sodium, 149 mEq/l)as well as elevated serum levels of lactate dehydrogenase (LDH; 566 IU/l)and β2 microglobulin 8.31 mg/l(0.8-2.34). Basal hormone analysis demonstrated hypopituitarism. Brain magnetic resonance imaging (MRI), however, showed a lesion infiltrating the floor of the third ventricle (21 × 18 × 15 mm), extending to encompass the entire pituitary stalk. The lesion appeared homogeneous and exhibited strong contrast enhancement after gadolinium administration. 18F-fluorodeoxyglucose (FDG)-positron emission tomography revealed enhanced FDG uptake of the lesion infiltrating the floor of the third ventricle, extending to encompass the entire pituitary stalk. In the biopsy of the clinically unaffected skin, immunohistochemistry revealed the presence of intravascular neoplastic cells positive for B-cell markers CD20, CD5, and MUM1, confirming the diagnosis of intravascular large B-cell lymphoma. Corticotropic and thyrotropic deficiencies were supplemented, and diabetes insipidus was treated with desmopressin. Additionally, the patient underwent R-CHOP chemotherapy, which resulted in a complete response. The patient remained in remission for six months following the cessation of chemotherapy. Hypopituitarism associated with IVLBCL was first described in 1986. A limited number of cases of IVLBCL involving functional abnormalities of the hypothalamic-pituitary axis have been reported. IVLBCL with hypothalamic or pituitary involvement can be effectively managed with hormone replacement therapy followed by chemotherapy. Consequently, timely identification of clinicopathological features is crucial for reducing mortality rates.
Volume 110
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2025 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more