Endocrine Abstracts

JOINT2057

Introduction: Schwannomas are tumors of the Schwann sheath of peripheral or cranial nerves. Visceral schwannomas are rare, accounting for 1 to 10 percent of all primary retroperitoneal tumors, and only a few cases of adrenal schwannomas have been reported.

Case report: A 23-year-old female patient consulted for abdominal pain, progressing in a context of weight loss of 12 kg over two months. Abdominopelvic CT scan suggested a right suprarenal retroperitoneal mass, seemingly originating from the adrenal gland, measuring 48×61 mm. It was well-defined, with a spontaneous density of 55 HU, heterogeneous, and contained calcifications. Biological tests ruled out pheochromocytoma, Conn’s adenoma, and cortisol-producing adenoma. A right adrenalectomy was performed without complications, revealing a benign schwannoma (spindle cell proliferation, PS100 expression).

Discussion/Conclusion: Schwannomas are often asymptomatic and incidentally discovered during imaging for an unrelated condition, as observed in our case. Radiological diagnosis is challenging. However, imaging typically shows a solid tumor with calcifications, a cystic component, and a well-defined capsule, allowing localization and assessment of its retroperitoneal positioning. Definitive diagnosis is confirmed by histological analysis of the surgical specimen (presence of Schwann cells, positivity for S-100).