Endocrine Abstracts

JOINT2680

Introduction: The relevance of the problem, the relationship between reproductive function disorders and thyroid pathology is actively discussed in the scientific literature since thyroid diseases are one of the most common endocrinopathies in women of reproductive age.

Materials and Methods: we used medical databases on the Internet: Medline/PubMed, EMBASE, EBSCO, the Cochrane Library. The results: The problem of the relationship between reproductive function disorders and thyroid pathology has become increasingly significant in recent years. This problem in women of reproductive age is currently of great theoretical and practical interest. In recent years, to examine the reproductive potential of women, the "ovarian reserve" has been assessed using certain indicators. According to Grigoryan O.R. et al.(2019), the vast majority of ovarian reserve indicators characterize the hormone-dependent stage of follicle growth. But discussions about the set and quantitative values of certain markers continue. Researchers from the Southwestern University of the Luzhou Clinic of China, who studied the relationship between ovarian reserve and thyroid function in women with infertility, conducted a retrospective analysis of data from 495 infertility patients who visited the clinic between January 2019 and December 2020. In this study, there was no significant correlation between ovarian reserve and thyroid function in women. A similar result was shown by a study conducted at the Center for Reproductive Medicine at the University Hospital of Brussels in 2015. The authors are Nikolaos P. et al. noted that this cross-sectional analysis could not demonstrate the relationship between autoimmune thyroiditis(AIT) and ovarian reserve. Other researchers Michalakisetal., (2011) revealed results that contradict previous studies. The research showed that women with DOR had higher TSH levels compared to women with normal ovarian reserve, and suggest that thyroid disorders may be associated with ovarian reserve. This study demonstrated a very strong positive correlation between serum autoantibody levels and autoantibody levels in follicular fluid, prompted several researchers to suggest that thyroid diseases can indeed affect ovarian reserve. It should be emphasized that numerous works with similar results are presented in the world literature.

Conclusions: Thus, a review of the literature showed that this problem remains controversial and there are many unresolved issues. To solve them, further researches and presence of scholars of various profiles are needed.

Key words: ovarian reserve, thyroid hypofunction, infertility.