Endocrine Abstracts

JOINT2336

Background: Joint hypermobility and instability are among the key risk factors for fractures in patients with Ehlers–Danlos syndrome (EDS). Abnormalities in thyroid hormone profile may be associated with the condition of bones and predisposition to fractures. The purpose of this study was to assess thyroid hormone profiles in patients with hypermobile or classical EDS and a history of fractures.

Material and Methods: The study involved a prospective assessment of 30 female patients with either hypermobile or classical EDS. The patients were divided into two groups. Group 1 comprised patients with no history of fractures (n = 13), and group 2 comprised patients with a history of fractures (n = 17). All patients underwent an assessment of thyroid hormones and parameters of calcium of phosphate metabolism.

Results: The assessed groups showed no differences in terms of such parameters as thyroid stimulating hormone (TSH) (1.691±0.772 vs. 2.439±1.644, P = 0.209 [µIU/ml]), free triiodothyronine (fT3) (3.542±0.802 vs. 3.262±0.495, P = 0.516 [pg/ml]), free thyroxine (fT4) (1.335±0.15 vs. 1.354±0.276, P = 0.630 [ng/dl]), anti-thymocyte globulin (ATG) (25.623±29.141 vs. 41.312±63.209, P = 0.99 [IU/ml]), or anti-thyroid peroxidase (ATPO) (49.385±139.919 vs. 26.259±31.054, P = 0.902 [IU/ml]) levels. There was no significant correlation between fractures and TSH (Spearman’s R 0.237, P = 0.207), fT3 (Spearmans R -0.124, P = 0.513), fT4 (Spearman’s R -0.496, P = 0.624), ATPO (Spearman’s R 0.029, P = 0.878), or ATG (Spearman’s R 0.029, P = 0.878) levels.

Conclusions: Positive history of fractures in patients with EDS is not associated with thyroid hormone profile abnormalities.