Endocrine Abstracts

JOINT3766

Background and Objectives: The aim of the study is to investigate the prevalence of thyroid nodules in children and adolescents with idiopathic central precocious puberty or early and fast puberty.

Methods: From 2020 to 2024, 645 children were diagnosed idiopathic central precocious puberty or early and fast puberty in our center, and accepted thyroid ultrasound examination were enrolled in our study. Results of ultrasound inspections as well as thyroid function were analyzed, and compared with 314 children who had underlying thyroid diseases.

Results: Among 645 children with idiopathic central precocious puberty or early and fast puberty, 254 (39.4%) had thyroid nodules, however, only 85 (27.1%) thyroid nodules were detected in 314 children with underlying thyroid diseases (P <0.05). In children with idiopathic central precocious puberty or early and fast puberty, thyroid nodules were mostly bilateral (70.4%), only 29.6% were unilateral. Ti-RADS showed that 174 cases were grade 1, 60 cases were grade 2, 3 were grade 3, 1 grade 4 and 1 grade 5. Thyroid function was normal, no hyperthyroidism or hypothyroidism was observed. anti-Thyroid antibodies were negative.

Conclusion: Unexpectedly detected thyroid nodules were more than expected in children with idiopathic central precocious puberty or early and fast puberty. The nodular were mostly bilateral. Thyroid ultrasound may be considered in such children and furthe investigations are needed.

Key words: thyroid, central precocious puberty, early and fast puberty, children.