Endocrine Abstracts

JOINT2375

Introduction: Metabolically associated fatty liver disease (MAFLD) frequent condition in people with obesity and lipid abnormalities. Hypothyroidism associated with fat abnormalities and predisposed to weight gain. We aimed to investigate frequency of fatty liver disease among women with hypothyroidism.

Material and Methods: 105 women in age 45-59 who lived in Andijan city which is iodine deficiency area BMI blood serum T3, T4, TSH, ALT, AST, bilirubin, total cholesterol (TCh), triglycerides (TG), LDLP, HDLP level were measured, aterogenic index were calculated. MAFLD degree were were detected by ultrasound.

Results: Obesity were determined by BMI and showed 1st degree in 38.2%, 2nd degree in 20.5%, 3rd degree in 7.8% of woman. Hypothyroidism were detected in 45.5% women. Blood TCh, TG, LDLP, HDLP and atherogenic index, blood ALT, AST level were higher than those without hypothyroidism. Interestingly in 41% of women with hypothyroidism were detected MAFLD in ultrasound. In patients who followed thyroid hormone replacement therapy MAFLD were lower than those who non-adhered which suggested about linkage between MAFLD and thyroid state.

Conclusion: MAFLD is a frequent clinical future in patients with hypothyroidism and depends from thyroid state. Adequate hormone replacement therapy can prevent MAFLD in patients with hypothyroidism.