Endocrine Abstracts

JOINT3934

Introduction: Follicular or vesicular cancers account for 5 to 10% of differentiated thyroid cancers (DTC) and are therefore the second most common cause of endocrine tumors after papillary thyroid cancer. They can be minimally or massively invasive, making them a more aggressive histological type compared to papillary carcinoma.

Objective: The objective of our study is to describe the clinical and evolutionary characteristics of vesicular thyroid tumors.

Materials and Methods: This is a retrospective descriptive study involving 34 patients treated in our service, between 1986 and 2024, diagnosed with vesicular thyroid carcinoma. Statistical analysis was performed using SPSS software.

Résults: The average age of our patients was 51.6 years. All the patients in our study were women. The most common presenting feature was the presence of an isolated goiter (67%), followed by an isolated thyroid nodule (8%). Bone metastases led to the diagnosis in one patient. One patient consulted for a nasal voice with progressive worsening and was diagnosed with carcinoma on an ectopic lingual thyroid. All our patients underwent total thyroidectomy, and lymph node dissection was indicated in only one patient. Radioactive iodine treatment was administered to 85% of the patients. All the carcinomas in our series were unifocal. Tumor size ranged from 0.5 cm to 7.5 cm. The development of locoregional and distant metastases (bone, lungs) was observed in one and two patients, respectively. Two patients developed ductal breast carcinoma during the follow-up. A complete remission was observed in 53% of the patients.

Conclusion: Our study reveals a female predominance of follicular thyroid carcinomas, with the majority of cases presenting as an isolated goiter. The overall prognosis is generally favorable, and the risk of local or distant recurrence is the key factor in guiding treatment.