ECEESPE2025 ePoster Presentations Thyroid (198 abstracts)
What is the role of Pro-inflammatory biomarkers in Hashimoto’s thyroiditis?
Vidya Paboju 1 , Ramesh Bangaraiahgari 2 , Rajesh Bangaraiahgari 1 , Laxmi Narayana Sripuram 1 , Sushmitha Sree Mekala 2 , Amith Anshuli Dubey 2 , Kundana Sree K M 2 , Varshitha Eadula 2 , Sabaretnam Mayilvaganan 2 & Ramakanth Bhargav Panchangam 3
1TRR Institute of Medical Sciences, Hyderabad, India; 2SGPGIMS, Lucknow, India; 3BGH, Vijayawada, India
JOINT2079
Introduction: Hashimoto’s thyroiditis (HT) is one of the most frequent organ specific autoimmune thyroid disease. Autoimmunity has been implicated as one of the main cause of HT. In this context, we set out study the role of Pro- inflammatory cytokines in HT.
Material and methods: This prospective case-control study was conducted on surgically managed HT patients. Institutional ethical committee approval was obtained. Diagnosis of HT was based on thyroid function tests, anti-TPO antibody titer, radionuclide scanning and histopathology. Exclusion criteria were subjects any systemic or chronic inflammatory disease or any medication which interferes with the normal function of the hypothalamic-pituitary-gonadal axis. Serum samples were collected from 20 HT subjects and 20 age matched healthy controls. Interleukin-6 (IL-6), Tumour necrosis factor-alpha (TNF-α) and high sensitive C reactive protein (hsCRP), Leptin levels were measured in all serum samples. Statistical analysis was performed by one way ANOVA with Dunnet’s test and Pearson correlation tests.
Results: The mean hSCRP level in GD and controls were 14.5 ± 2.9 mg/ml and 6.4 ± 1.6 mg/ml respectively. The mean TNF-α level, IL-6 level and Leptin levels were 232 ± 25 pg/ml, 12.7 ± 4.4 pg/ml and 33 ± 4.7 ng/ml respectively. There was statistically significant difference of all the pro-inflammatory cytokines compared to controls (P value < 0.05).
Conclusions: This study shows raised titers of pro-inflammatory markers – IL-6, TNF-α and hsCRP, leptin correlated with HT suggesting a significant pathophysiological role. But, the exact immuno-modulatory role and pathogenetic mechanism needs more research. (Key words: Hashimoto’s thyroiditis; Tumour necrosis factor; Interleukin-6; Goiter; Auto-immunity; Leptin)
Volume 110
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Endocrine Abstracts
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