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Endocrine Abstracts (2025) 110 EP1544 | DOI: 10.1530/endoabs.110.EP1544

1University of Sousse Faculty of Medicine of Sousse, Sousse, Tunisia


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Introduction: Riedel’s thyroiditis is a rare form of chronic thyroid inflammation characterized by extensive fibrosis extending beyond the thyroid gland, often mimicking thyroid malignancy. The objective of this study is to analyze the epidemiological, clinical, and histopathological characteristics of this condition, along with its evolutionary patterns and therapeutic approaches.

Methods: We report three cases of Riedel’s thyroiditis managed at the ENT and Cervicofacial Surgery Department of Farhat Hached Hospital in Sousse.

Results: Our series included two men and one woman, with a mean age of 41 years. The primary complaint in all cases was an anterior lower cervical swelling, without any compressive symptoms. Clinical examination revealed a well-defined, firm, painless, and mobile anterior cervical mass with intact overlying skin and no palpable cervical lymphadenopathy. Vocal cord mobility was preserved in all patients. Cervical ultrasound was performed in all cases, and one patient underwent thyroid scintigraphy. The initial surgical approach consisted of lobectomy with isthmectomy in all patients. In one case, the thyroid lobe was strongly adherent to the trachea, while in another case, it was adherent to the infrahyoid muscles. The diagnosis of Riedel’s thyroiditis was confirmed histopathologically. Additionally, one patient was found to have an intrathyroidal micropapillary carcinoma of the follicular variant, necessitating completion thyroidectomy.

Conclusion: Riedel’s thyroiditis remains an enigmatic entity with an unknown etiology. Its management involves a discussion between conservative surgery and medical treatment, including corticosteroids, tamoxifen, and mycophenolate mofetil, with treatment protocols potentially guided by additional paraclinical findings.

Volume 110

Joint Congress of the European Society for Paediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE) 2025: Connecting Endocrinology Across the Life Course

European Society of Endocrinology 
European Society for Paediatric Endocrinology 

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