Investigating the role of selenium and inositol supplementation in managing hashimoto

Hadi Tabesh; Hamidreza Bazrafshan; Narges Kashanivahid

doi:10.1530/endoabs.110.EP1617

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Endocrine Abstracts (2025) 110 EP1617 | DOI: 10.1530/endoabs.110.EP1617

ECEESPE2025 ePoster Presentations Thyroid (198 abstracts)

Investigating the role of selenium and inositol supplementation in managing hashimoto’s thyroiditis: a preliminary observational study

Hadi Tabesh ¹ , Hamidreza Bazrafshan ^2,3 & Narges Kashanivahid ²

Author affiliations

¹University of Tehran, Tehran, Iran; ²Dr. Bazrafshan Clinic, Tehran, Iran; ³University Hospital, Munich, Germany

JOINT3906

Hashimoto’s thyroiditis (HT) is an autoimmune disorder of the thyroid marked by increased levels of anti-thyroid antibodies and a gradual decline in thyroid function. This observational study investigates the effects of supplementing selenium and inositol three times a week on antibody levels in five patients diagnosed with HT. Throughout the treatment period, there was a notable decrease in the levels of anti-thyroid peroxidase (TPO) and anti-thyroglobulin (TG) antibodies. After two years of follow-up, four patients showed complete remission of HT, particularly those who maintained good mental health and engaged in regular exercise. These results indicate that selenium and inositol supplementation may have a positive impact on autoimmune activity in HT, potentially enhancing thyroid function and overall patient outcomes. However, further controlled studies are necessary to validate these initial findings and develop standardized treatment guidelines.