Endocrine Abstracts

JOINT3844

Background: Non-functioning adrenal adenomas (NFA) are prevalent tumors frequently associated with metabolic disorders such as obesity, hypertension, dyslipidemia, insulin resistance (IR), impaired glucose tolerance, metabolic syndrome (MetS), and osteoporosis. These conditions occur at higher prevalence in NFA patients compared to the general population. Since traditional risk assessments may be insufficient, novel atherogenic indices could improve cardiovascular risk (CVD) risk assessment in NFA patients.

Aim: This study aimed to characterize patients with NFA and CVD risk by analyzing novel atherogenic indices (TyG index, TyG-BMI index, LCI, Castelli Risk Index_2, AC, AIP, TG/HDL-C, MetS-IR), fasting glucose, and anthropometric measurements such as BMI and WHR.

Material and methods: This study enrolled of 106 patients aged >40 with NFA. CVD risk was evaluated based on Systematic Coronary Risk Evaluation 2 (SCORE2) and Systematic Coronary Risk Evaluation 2-Older People (SCORE2-OP) algorithms. Biochemical parameters (fasting blood glucose, total cholesterol levels (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), triglicerydes (TG) were measured, followed by the computation of atherogenic indices such as Castelli’s risk Index_I, Castelli’s risk Index_II, Atherogenic index of plasma (AIP), Atherogenic coefficient (AC), Lipoprotein combine index (LCI), TG/HDL-ratio, Metabolic Score for insulin resistance (METS-IR), Triglyceride-Glucose index (TyG index), Triglyceride-Glucose body mass index (TyG BMI index) were computed. Anthropometric parameters were assessed using standard methods, including body weight, height, waist circumference, and hip circumference. Based on these, BMI and WHR were calculated.

Results: The median fasting glucose level was 101.5 mg/dl (94-109 mg/dl) in NFA patients. The mean TC was 212.0±46.3 mg/dl, the median HDL-C was 60.2 mg/dl (11.9-153.8 mg/dl), the mean LDL-C was 124.2±42.0 mg/dl, and the median TG was 107.0 mg/dl (43.0-509.0 mg/dl) The mean TyG index was 8.6±0.5, and the median TyG BMI index was 240.4 (9.3-367.8). NFA patients have the LCI of 13.7 (2.0-170.5). The median Castelli’s Risk Index_I was 3.3 (1.6-20.0), and the median Castelli’s Risk Index_II was 1.9 (0.6-9.1). The median AC was 2.3 (0.6-19.0), and the mean AIP was -0.09±0.2. The median TG/HDL-C was 1.7 (0.5-12.0). METS-IR demonstrated the mean value 39.9±9.0. The mean BMI was 28.3±4.5, and the mean WHR was 0.9±0.08.

Conclusions: This study highlights significant variability in atherogenic indices and anthropometric measurements in patients with non-functioning adrenal adenomas (NFA) and cardiovascular disease (CVD) risk. The findings suggest that novel indices like the TyG index and MetS-IR may provide a more accurate assessment of CVD risk in NFA patients, warranting further investigation into their clinical significance.