Echocardiographic evaluation of functional and morphological alterations in obesity: a comparison between obese individuals with and without Metabolic Syndrome

Ilijevska Cvetanka Volkanovska; Valentina Andova; Nakova Valentina Velkoska; Minova Natasha Nedeska; Taner Hasan; Ismail Ljubica Georgievska

doi:10.1530/endoabs.110.EP3

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Endocrine Abstracts (2025) 110 EP3 | DOI: 10.1530/endoabs.110.EP3

ECEESPE2025 ePoster Presentations Adrenal and Cardiovascular Endocrinology (170 abstracts)

Echocardiographic evaluation of functional and morphological alterations in obesity: a comparison between obese individuals with and without Metabolic Syndrome

Cvetanka Volkanovska Ilijevska ¹ , Valentina Andova ² , Valentina Velkoska Nakova ³ , Natasha Nedeska Minova ⁴ , Taner Hasan ⁵ & Ljubica Georgievska Ismail ²

Author affiliations

¹University Clinic of Endocrinology, Diabetes and Metabolic Disorders SS. Cyril and Methodius University, Skopje, Macedonia; ²University Clinic of Cardiology, Medical Faculty, Ss. Cyril and Methodius, Skopje, Macedonia; ³Faculty of Medical Sciences, Goce Delcev University, Internal medicine, Stip, Macedonia; ⁴General City Hospital 8 thSeptember, Skopje, Macedonia; ⁵General City Hospital 8th September, Skopje, Macedonia

JOINT3739

Background: Obesity has been identified as an independent risk factor for heart failure. The risk of heart failure is dependent on body mass index (BMI).

Aim: This study aimed to examine the effects of obesity on myocardial function and morphology, and to compare these alterations in obese individuals with and without metabolic syndrome (MetS+/- group).

Methods: A total 125 subjects with a BMI more than 25 kg/m² underwent metabolic and clinical evaluation. An evaluation of conventional echocardiographic parameters and cardiac deformation by 2D speckle tracking echocardiography was conducted. The mean age was 45.0 ± 9.6 years (female: 58.7%), and the average BMI was 35.01 ± 6.53. In 74% of the subjects, the duration of overweight/obesity was over 10 years. Metabolic syndrome was diagnosed in 54 patients (70%). Two dimensional echocardiographic evaluation showed that the MetS⁺ group had a larger LA maximal volume and a LA volume indexed for body height than the MetS^- group, but the differences were not statistically significant (P = 0.068, P = 0.098, respectively). The MetS⁺ group had significantly lower LA ejection fraction compared to the MetS^- group (LAEF% = 46.89 vs 50.13, P = 0.03). Regarding the strain analysis, it was also found that the MetS⁺ group had significantly lower values for the peak longitudinal deformation of LA in the reservoir phase (PALS) (P = 0.008). The LV mass indexed by height (LVMh) significantly differed between the two groups, despite both being within the reference limits (P = 0.016). Conversely, both groups exhibited higher LV mass indexed by the square of height (LVMh2), with the MetS⁺ group demonstrating a significantly higher values (P = 0.002). Moreover, the mean values of global longitudinal strain (GLS) of the left ventricle were below the reference range in both groups, but significantly lower in the MetS+ group compared to the MetS^- group (GLS = -20.7 vs -22.7, P = 0.016) The peak mitral annular descent velocity (s’TDI) and the late diastolic velocity were significantly reduced in MetS⁺ (P = 0.019 and P = 0.033, respectively).

Conclusion: Obesity itself causes substantial morphological and functional myocardial alterations, in particular if accompanied by metabolic abnormalities.