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Endocrine Abstracts (2025) 110 EP402 | DOI: 10.1530/endoabs.110.EP402

1National Institute of Nutrition and Food Technology, Department of Nutritional Diseases (D), Tunis, Tunisia


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Background: Pregnancy represents a critical period in the life of a woman with diabetes, as it leads to weight gain and alters glycemic control as well as lipid profile. The aim of our study was to determine the evolution of glycemic profile of a group of diabetic women after childbirth.

Methods: We conducted a prospective descriptive study in pregnant women treated for pregestational diabetes and followed at the Department of Nutritional Diseases «D» of the National Institute of Nutrition of Tunis. Glycemic profile was monitored during pregnancy and six months postpartum.

Results: We collected 30 diabetic patients with a mean age of 32.2±4 years [ext :23-39]. Most patients had type 2 diabetes (80%). The mean duration of diabetes was 3.6±2.9 years in patients with type 2 diabetes and 13.6±7.3 years in patients with type 1 diabetes. During pregnancy: The mean glycated hemoglobin (A1C) was 7.8±1.6% with a range from 5.9% to 12%. The occurrence of a hypoglycemic episode was reported in 22% of the patients. After six months of childbirth, only 10% of babies were exclusively breastfed, while half were formula-fed. The mean fasting blood glucose level was 10,11±4,5 mmol/l, and the mean A1C was 8,19±2,05%. Only 3 patients reported experiencing hypoglycemic episodes. We observed a lower mean A1C level in cases of exclusive breastfeeding (P = 0.035).

Conclusion: Six months after childbirth, we observed an increase in the glycated hemoglobin level and a decrease in the number of hypoglycemic episodes. Further studies on a larger scale might be needed.

Volume 110

Joint Congress of the European Society for Paediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE) 2025: Connecting Endocrinology Across the Life Course

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