Endocrine Abstracts

JOINT3973

Introduction: In diabetic patients, planning conception is essential to prevent embryofetopathy and the progression of diabetes complications in the mother.

Study Objective: The aim of our study is to analyze the clinical and metabolic profile of a group of pregnant women with Gestational Diabetes (GD) and to determine the predictive factors for the use of insulin therapy.

Materials and Methods: This is a retrospective study conducted in our Department, including 368 patients with gestational diabetes. Statistical analysis was performed using SPSS software.

Results: The average age of the patients was 32 years. The average term for diagnosing gestational diabetes was 25.2 weeks of amenorrhea. 22% had a history of GD. Insulin therapy was required in 27% of cases. The average total insulin dose required was 0.5 units/kg/day at the end of third trimester. A regimen with three rapid insulin injections was prescribed for 20 pregnant women. For the remaining patients, a basal-bolus regimen was necessary to achieve targets. The need for insulin therapy was more frequent when GD was diagnosed earlier (<24 weeks) (P = 0.02), in patients older than 35 years (P = 0.02), and with higher fasting blood glucose levels and average glycated hemoglobin levels (P = 0.01).

Conclusion: This study demonstrated that earlier diagnosis of GD, advanced maternal age, and elevated fasting blood glucose levels are predictive factors for insulin therapy, consistent with previous studies. However, a history of macrosomia, recurrence of GD, and diabetic heredity were frequently associated with patients treated with insulin but without statistically significant results.