Correlation between visceral fat, insulinresistance and age in type 1 diabetes patients

Samir Mkaouer; Zeineb Rekaya; Meriem Yazidi; Elyes Kamoun; Nadia Khessairi; Ibtissem Oueslati; Fatma Chaker; Melika Chihaoui

doi:10.1530/endoabs.110.EP448

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Endocrine Abstracts (2025) 110 EP448 | DOI: 10.1530/endoabs.110.EP448

ECEESPE2025 ePoster Presentations Diabetes and Insulin (245 abstracts)

Correlation between visceral fat, insulinrésistance and age in type 1 diabetes patients

Samir Mkaouer ¹ , Zeineb Rekaya ¹ , Meriem Yazidi ¹ , Elyes Kamoun ¹ , Nadia Khessairi ¹ , Ibtissem Oueslati ¹ , Fatma Chaker ¹ & Melika Chihaoui ¹

Author affiliations

¹CHU La Rabta, Endocrinology Department, Tunis, Tunisia

JOINT397

Introduction: The prevalence of metabolic syndrome (MS) and insulin resistance (IR) increases with age. This association is poorly studied in patients with type 1 diabetes (T1D). The aim of our study was to evaluate the association between IR, MS and age in young adults with T1D.

Methods: We conducted a cross-sectional study including 68 patients with T1D. The study subjects were young adults, aged between 18 and 45 years. Each patient underwent a physical examination (anthropometric parameters and blood pressure), a fasting biological sample collection for the measurement of HbA1c, lipid parameters and C reactive protein (CRP), an evaluation of body composition by DXA Scan to measure the visceral fat mass (VFM). Visceral fat mass proportion (%VFM) was calculated by the formula: [VFM (g)/Weight (g)] x 100. High visceral fat mass (HVF) was defined by a %VFM >1,1 in men and >0,7 in women. MS was diagnosed according to the International Federation of Diabetes (IDF) criteria.

Results: The study population consisted of 29 men (42.6%) and 39 women (57.4%). The mean age was 29.4±7.23 years. The median duration of diabetes was 11 years (4.2–17.0), with a range from 1 to 29 years. MS was observed in 14 patients (20.6%). HVF was present in 15 patients (23.4%). MS was not associated with age in T1D patients (P = 0.621). T1D patients with HVF were significantly older than T1D without HVF (34.3±8.38 vs 28.3±6.40; P = 0.005). An age above 30 years old was significantly more observed in T1D patients with HVF than patients without HVF (73% vs 40,8%; P = 0.027).

Conclusion: In our study, age was not associated with MS in patients with T1D. This could be explained by the young age of our population. Yet an age above 30 was associated with visceral fat which is correlated with IR and can increase cardiovascular risk.