Prevalence of sarcopenia in indians with type 1 diabetes mellitus

Vibhu Khare; Nilanjan Sengupta; Soumik Goswami; Arjun Baidya; Rajat Deb; Joydip Datta

doi:10.1530/endoabs.110.EP500

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Endocrine Abstracts (2025) 110 EP500 | DOI: 10.1530/endoabs.110.EP500

ECEESPE2025 ePoster Presentations Diabetes and Insulin (245 abstracts)

Prevalence of sarcopenia in indians with type 1 diabetes mellitus

Vibhu Khare ¹ , Nilanjan Sengupta ¹ , Soumik Goswami ¹ , Arjun Baidya ¹ , Rajat Deb ¹ & Joydip Datta ¹

Author affiliations

¹Nil Ratan Sircar Medical College, Kolkata, Endocrinology, Kolkata, India

JOINT1723

Objective: Sarcopenia is an ignored and underdiagnosed condition in patients with diabetes. India houses the largest number of patients with type 1 diabetes but lacks data on sarcopenia prevalence in them. We estimated the prevalence of sarcopenia in type 1 diabetes patients and compared it with age- and sex- matched healthy participants.

Research design and methods: Patients with type 1 diabetes and age ≥ 12 years were included and patients with pregnancy, lactation and any condition which can affect skeletal muscle properties were excluded. A total of 93 patients of type 1 diabetes and an equal number of age- and sex-matched healthy participants were included for comparison in a cross-sectional and observational study. For sarcopenia assessment, skeletal muscle mass, strength and function were measured and cutoffs for diagnosis were taken according to the Asian Working Group on Sarcopenia 2019 guidelines.

Results: The prevalence of sarcopenia in T1DM patients was significantly higher than controls (30.1% vs 11.8%) with an odds ratio of 3.2 and was more common in adults compared to adolescents (36.7% vs 12%). Gender, total daily dose of insulin, eGFR and IGF-1 levels did not have a correlation with sarcopenia in T1DM.

Conclusions: This study shows that patients of type 1 diabetes have an approximately three times higher prevalence of sarcopenia when compared to the general population with nearly 1 out of 3 type 1 diabetes patients affected by the condition.