Endocrine Abstracts

JOINT2360

Diabetes mellitus (DM) is characterized by a global metabolic disorder, not only of carbohydrate but also lipid metabolism. Consumption of high-calorie diets and lack of physical activity in the long term lead to the accumulation of very low-density lipoprotein cholesterol (VLDL-C), which accelerates the development of atherosclerosis and is a major risk factor for cardiovascular diseases. The purpose of the work was to study the indicators of lipid metabolism in the blood of patients with diabetes of varying severity. The mild form is characterized by a glucose level of up to 8 mmol/l on an empty stomach, the moderate form is up to 14 mmol/l, the severe form of diabetes is over 14 mmol/l. Indicators of total blood lipids in the control were 5.20±0.33 g/l and significantly increased at all degrees of severity (P<0.05). Total cholesterol in the control was 4.89±0.10 mmol/l; in diabetes it significantly increased to 6.0±0.17 in mild form, to 5.95±0.11 in moderate form, to 5.79± 0.16 mmol/l (P<0.05) in severe cases. The level of triglycerides in the control was 1.56±0.21 mmol/l, with mild diabetes it was significantly increased to 1.84±0.05, with moderate severity - 2.25±0.04, with severe diabetes - 2.98±0.34 mmol/l (P<0.05). VLDL and LDL cholesterol in the control corresponded to 10.47±1.24 mmol/l. In the mild form, this indicator was increased to 26.36±3.51 (P<0.01), in the moderate form – to 26.41±2.04, in the severe form – to 15.35±0.31 mmol/l. At the same time, HDL cholesterol significantly decreased in all groups. The lipid spectrum of patients with diabetes shows a significant increase in atherogenic lipoproteins and a decrease in antiatherogenic lipoproteins.