Influence of degenerative complications of diabetes on the occurrence of infections

Yesmine Elloumi; Wissal Abbes; Salah Dhoha Ben; Maryem Akacha; Khouloud Boujelben; Nadia Charfi; Mouna Mnif; Mohamed Abid; Mouna Elleuch; Majdoub Nabila Rekik

doi:10.1530/endoabs.110.EP530

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Endocrine Abstracts (2025) 110 EP530 | DOI: 10.1530/endoabs.110.EP530

ECEESPE2025 ePoster Presentations Diabetes and Insulin (245 abstracts)

Influence of degenerative complications of diabetes on the occurrence of infections

Yesmine Elloumi ¹ , Wissal Abbes ¹ , Dhoha Ben Salah ¹ , Maryem Akacha ¹ , Khouloud Boujelben ¹ , Nadia Charfi ¹ , Mouna Mnif ¹ , Mohamed Abid ¹ , Mouna Elleuch ¹ & Nabila Rekik Majdoub ¹

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¹Hedi Chaker University Hospital, Endocrinology Department, Sfax, Tunisia

JOINT987

Background: Infections in diabetic patients represent a significant clinical challenge, particularly in those with degenerative complications of diabetes. The potential role of these complications in increasing infection risk warrants further investigation. This study seeks to examine the association between degenerative complications and the occurrence of infections.

Methods: A retrospective study was conducted involving diabetic patients hospitalized in the Endocrinology Department over one year who had undergone an evaluation of diabetes-related complications within the previous six months.

Results: The study included 195 patients, comprising 91 men and 104 women, with 29% having type 1 diabetes and 71% having type 2 diabetes. A significant difference was observed between the two groups in the prevalence of infectious complications (37% in type 2 diabetes versus 15% in type 1 diabetes ; P< 0.05). The most common bacterial infections in this population were urinary tract infections (n = 21), which were more frequent in women (P< 0.05), soft tissue infections (n = 21), with 40% involving the foot, and bronchopulmonary infections (n = 12). The frequency of urinary tract infections, septicemia, and bronchopulmonary infections was not influenced by the presence of degenerative complications. However, foot infections were more frequent in patients with lower limb arteriosclerosis obliterans and those with sensorimotor polyneuropathy.

Conclusion: We highlight that among the most common bacterial infections in hospitalized diabetic patients, only foot infections are more frequent in the presence of peripheral artery disease or sensorimotor neuropathy. This underscores the importance of hygiene precautions and proper foot care.