ECEESPE2025 ePoster Presentations Diabetes and Insulin (245 abstracts)
Type 2 diabetes-related features in patients with metabolic associated steatotic liver disease
Yesmine Elloumi 1 , Mouna Elleuch 1 , Younes Derbel 1 , Khouloud Boujelben 1 , Hadjkacem Faten 1 , Nadia Charfi 1 , Mouna Mnif 1 , Dhoha Ben Salah 1 & Nabila Mejdoub Rekik 1
1Hedi Chaker University Hospital, Endocrinology Department, Sfax, Tunisia
JOINT464
Background: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder commonly associated with various comorbidities, including Metabolic Associated Steatotic Liver Disease (MASLD). The overlap between these conditions presents significant challenges in both diagnosis and management. Understanding the specific diabetes-related characteristics in patients with T2D and MASLD is essential for improving clinical outcomes. This study explores the clinical features of T2DM patients with MASLD.
Methods: This retrospective study was conducted on T2DM patients with confirmed MASLD, who were followed at the Endocrinology-Diabetology Department of Hedi Chaker University Hospital in Sfax, Tunisia, over a 12-year period.
Results: This study was conducted on 101 diabetic patients. The mean age of diabetic patients with MASLD was 53.7 (±15.2) years, with a female predominance of 62.4%. T2DM was diagnosed at a mean age of 48 [40-57] years. They had a median HbA1c of 9% [6.8-11.3] and a median blood glucose level of 10.3 mmol/l [4.5-16.1]. After a median duration of 3 [0.7-10] years, 54.5% of these patients developed microvascular complications, while 31.7% had macrovascular complications. The most common microvascular complications were diabetic nephropathy (40.9%) and neuropathy (35.4%), followed by diabetic retinopathy (25.7%) and erectile dysfunction (23.1%). Positive albuminuria was detected in 35.6%, and impaired glomerular filtration rate (GFR) was observed in 27.7%, predominantly at stages CKD-G3 (10.9%) and CKD-G4 (15.8%). Regarding macrovascular complications, ischemic heart disease (26.7%) and peripheral arterial disease (13.9%) were most frequently noted. Nearly half of the patients (48.5%) were treated with oral medications alone. In 21.8% of cases, insulin therapy was initiated, either as monotherapy (12.9%) or in combination with oral antidiabetic drugs (8.9%).
Conclusion: Our study provides insights into how the features of diabetes may contribute to the development and progression of MASLD.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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