ECEESPE2025 ePoster Presentations Diabetes and Insulin (245 abstracts)
Mycosis fungoides and diabetes mellitus: is there a link?
Oumaima Dimassi 1 , Khouloud Boujelben 1 , Mouna Elleuch 1 , Malek Hadrich 1 , Mouna Mnif 1 , Nadia Charfi 1 , Faten Haj Kacem Akid 1 , Mohamed Abid 1 , Dhoha Ben Salah 1 & Nabila Rekik Majdoub 1
1Department of Endocrinology Hedi Chaker Hospital, Sfax, Tunisia
JOINT2530
Background: Mycosis fungoides (MF) is the most common type of primary cutaneous T-cell lymphoma, often presenting with chronic nonspecific skin lesions that can mimic inflammatory dermatoses. Diabetes mellitus (DM) is a metabolic disorder frequently diagnosed incidentally during routine evaluations. The coexistence of MF and DM is rare, and their potential pathophysiological link remains unclear.
Case Presentation: A 63-year-old woman with a family history of hypertension and type 2 diabetes mellitus, and a personal history of dyslipidemia, treated with atorvastatin, presented with progressive, pruritic, erythematous plaques with fine scaling, well-demarcated pigmentation, and atrophic hypopigmented areas. Some lesions exhibited a wrinkled skin appearance. These lesions had been evolving over the past nine months with diffuse involvement of the trunk and extremities. A skin biopsy was performed at the Department of Dermatology and histopathological analysis with immunohistochemistry confirmed the diagnosis of mycosis fungoides. The patient was started on topical corticosteroids and retinoids. During the diagnostic workup, routine laboratory investigations revealed newly diagnosed diabetes mellitus. The patient was subsequently initiated on oral antidiabetic therapy. Under treatment, her glycemic control improved, and her cutaneous lesions stabilized.
Discussion: MF is characterized by dysregulated T-cell activation, leading to increased levels of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-17. These cytokines are also implicated in insulin resistance and β-cell dysfunction in DM. Chronic immune stimulation in MF could contribute to metabolic disturbances, potentially increasing the risk of DM.
Conclusion: This case highlights the importance of metabolic screening in patients presenting with unexplained dermatological symptoms. Further research is needed to explore potential links between mycosis fungoides and diabetes mellitus.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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