Endocrine Abstracts

JOINT40

Objectives: The diabetic patients are subjects at high cardiovascular risk. Vitamin D plays a significant role in minimizing chronic metabolic syndromes such as type 2 DM and cardiovascular diseases. Vitamin D deficiency increased CVD risk in poor glycemic control in diabetics. The objective of our study is to describe metabolic profile in type 2 diabetics with vitamin D deficiency and its associations with CVD.

Methods: Included a total of 64 type 2 diabetics in whom a vitamin D dosage was carried out. The presence of CVD was determined based on medical records. Control of diabetes was assessed based on HbA1C levels.

Results: The average age of our patients was 57.04 years ±11.05. 45 patients had poor glycemic control and the other had good glycemic control. Patients with poor control had a significantly higher level of total cholesterol (TC), triglyceride (TG), and non-high-density lipoprotein lipase cholesterol (non-HDL-C), compared to patients with good glycemic control. Was observed significant negative correlation of vitamin D with lipid markers. Hyperuricemia was present in 20 patients. 65% of patients had high blood pressure under medication, 21 patients were on ACE- inhibitor or ARB, 9 on calcium channel blockers, 5 on thiazide diuretics and 7 on beta blockers.

Conclusions: Patients with T2DM who are at risk for diabetic complications under poor glycemic control should be advised for vitamin D measurement, and vitamin D supplementation may reduce the risk of CVD.