ECEESPE2025 ePoster Presentations Diabetes and Insulin (245 abstracts)
Pancreatic diabetes: diagnostic, therapeutic, and evolutionary particularities
Emna Naccache 1 , Sawsen Essayeh 1 , Rihab Laamouri 1 , Sabrine Mekni 1 , Nadia Mchirgui 1 , Khiari Karima 1 , Imen Rojbi 1 & Ibtissem Ben Nacef 1
1Charles Nicolle Hospital, Endocrinology Department, Tunis, Tunisia
JOINT2216
Introduction: Pancreatic diabetes, or type 3c diabetes, is a specific form of diabetes caused by pancreatic dysfunction due to diseases affecting its insulin production capacity. It remains underdiagnosed, often leading to a delayed diagnosis. The aim of this study is to analyze the diagnostic, therapeutic, and evolutionary particularities of this form of diabetes.
Materials and Methods: This is a retrospective descriptive study including 12 patients followed for pancreatic diabetes at the endocrinology department of Charles Nicolle Hospital in Tunis between 2019 and 2024.
Results: The median age was 60 ± 11.6 years, with a male-to-female ratio of 11.5. The median duration of diabetes was 5 ± 6.7 years. Two patients had pancreatic cancer, while ten had pancreatitis, including four with acute pancreatitis and six with chronic pancreatitis. Additionally, four patients had a history of pancreatic surgery. Half of the patients were treated with basal human insulin and basal insulin analogs, and a quarter required rapid insulin. All patients had poorly controlled diabetes, with a fasting blood glucose level of 2.46 ± 1.56 g/l and an HbA1c of 10.2 ± 2.17%. Four patients exhibited unstable diabetes, with hypoglycemia occurring in approximately 30% of cases. Macrovascular and microvascular complications were present in half and one-third of the patients, respectively.
Conclusion: Pancreatic diabetes remains a rare form of diabetes that requires early diagnosis. Its management is challenging due to its instability, the very high risk of hypoglycemia, and its association with serious conditions, such as chronic pancreatitis or pancreatic tumors.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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