Unexpected presentation of pancreatic metastasis in B-cell Lymphoma

Imen Mhiri; Yesmine Elloumi; Fatma Chaltout; Ghada Mani; Issam Jardak; Mohamed Maaloul; Fatma Hamza; Salma Charfeddine; Khalil Chtourou

doi:10.1530/endoabs.110.EP653

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Endocrine Abstracts (2025) 110 EP653 | DOI: 10.1530/endoabs.110.EP653

ECEESPE2025 ePoster Presentations Endocrine Related Cancer (100 abstracts)

Unexpected presentation of pancreatic metastasis in B-cell Lymphoma

Imen Mhiri ¹ , Yesmine Elloumi ² , Fatma Chaltout ¹ , Ghada Mani ¹ , Issam Jardak ¹ , Mohamed Maaloul ¹ , Fatma Hamza ¹ , Salma Charfeddine ¹ & Khalil Chtourou ¹

Author affiliations

¹Habib Bourguiba Univesity Hospital, Nulcear Medicine Department, Sfax, Tunisia; ²Hedi Chaker University Hospital, Sfax, Tunisia

JOINT1311

Background: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, characterized by its aggressive nature and diverse clinical presentations. While DLBCL primarily affects lymphoid tissues, extranodal involvement can occur in various organs, including the pancreas. Pancreatic involvement in DLBCL is rare and poses unique diagnostic and therapeutic challenges.

Case report: We present the case of a 44-year-old female with no prior history of diabetes or endocrine disorders, who initially presented with an inguinal adenopathy. A biopsy of the inguinal lymph node revealed giant cell lymphoma, characterized by CD20+ positivity and a high Ki-67 proliferative index of 90%. Subsequent imaging, including a PET-FDG scan, revealed extensive involvement of the entire pancreas by the lymphoma. Notably, despite the widespread pancreatic infiltration, there was an absence of any pancreatic endocrine dysfunction, including diabetes or hypoglycemia.

Conclusion: This case highlights the unusual presentation of lymphoma with significant pancreatic involvement and without the typical endocrine disturbance emphasizing the need for careful monitoring and underscoring the variability in clinical presentations of pancreatic lymphoma.