Endocrine Abstracts

JOINT2895

Environmental stress is a known modulator of immune function and disease onset in autoimmune disorders such as type 1 diabetes (T1D). Using Non-Obese Diabetic (NOD) mice, a well-established model for T1D, we investigated the effects of sustained stress exposure in a conflict zone. NOD mice develop diabetes due to immune-mediated destruction of pancreatic β-cells, and their disease progression is influenced by external stressors. During a prolonged period of regional hostilities, we observed a significant increase in diabetes onset rates, exceeding those reported under standard conditions. Despite maintaining strict hygiene protocols, our facility experienced frequent environmental disruptions, including power fluctuations and abrupt evacuations, leading to sustained stress exposure. Previous studies have linked stress to immune dysregulation, and our findings provide direct evidence that chronic stress accelerates T1D onset. These results highlight the profound impact of environmental stress on autoimmunity and offer insights into its potential role in human autoimmune disease progression.