ECEESPE2025 ePoster Presentations Growth Axis and Syndromes (132 abstracts)
Glucose metabolism disorders in patients with acromegaly
Yesmine Elloumi 1 , Wissal Abbes 1 , Dhoha Ben Salah 1 , Khouloud Boujelben 1 , Hadjkacem Faten 1 , Nadia Charfi 1 , Mouna Mnif 1 , Mohamed Abid 1 , Mouna Elleuch 1 & Nabila Rekik Majdoub 1
1Hedi Chaker University Hospital, Endocrinology Department, Sfax, Tunisia
JOINT848
Background: Glucose metabolism disorders are common complications of acromegaly, contributing significantly to morbidity in affected patients. Understanding the factors associated with these disorders is essential to optimize their management. This study aims to investigate the frequency and the characteristics of glucose metabolism disorders in patients with acromegaly.
Methods: This was a retrospective study involving 32 patients with acromegaly treated at the Endocrinology Department of Hedi Chaker University Hospital, Sfax, over a 16-year period. The patients were divided into two groups: Group 1, consisting of 24 patients with glucose metabolism disorders, and Group 2, consisting of 8 patients without such disorders.
Results: la fréquence du trouble du métabolisme glucidique était de 75%. Diabetes Mellitus was identified in 17 patients (71%), while glucose intolerance was noted in 7 cases (29%). Glucose metabolism disorders were diagnosed, on average, 7.5 years after the onset of acromegaly. Treatment consisted of dietary measures alone in 11 cases (45%), oral antidiabetics in 7 cases (29%), insulin alone in 3 cases (12.5%), and a combination of insulin and oral antidiabetics in 3 cases. The underlying cause of acromegaly was a Somatotroph macroadenoma in 14 patients, microadénoma in 7 patients, and ectopic secretion of growth hormone-releasing hormone in 1 patient. Among 20 patients who received treatment for acromegaly, 5 showed improvement in glucose metabolism. After successful treatment of acromegaly, the overall improvement rate in glucose metabolism was 21%.
Conclusion: Acromegaly is a multifaceted disease that requires careful evaluation and management. Advancing our understanding of its metabolic impact is crucial for optimizing care strategies.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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