Endocrine Abstracts

JOINT1143

Introduction: Acute Myocardial Infarction (AMI) frequently accompanied with hyperglycemia, either transient or due to impaired glucose tolerances or DM. Usually hyperglycemia during AMI in healthy non-diabetic person viewed as a reflection to the acute stress condition. Despite there a many studies regarding that transient hyperglycemia, management is under discussion. The aim of our study was estimation of frequency of hyperglycemia in people with AMI.

Materials and Methods: Cases of AMI in Bukhara city were analyses based on two main hospitals in Bukhara during 2022/2023 were analyzed retrospectively by patients chart. Second part of investigation were conducted prospectively with daily multiple blood sugar level control.

Results: Medical records from 997 patients, whose were admitted to the hospitals due to AMI shown that 66% of patients has Dm². There were no information about transient hyperglycemia. Analysis of early in hospital death rate were estimated about 10.2% and were detected only in patients with Dm². Prospective study were conducted in 170 people who admitted into mentioned above hospitals due to AMI. Among in-hospital admitted AMI patients 104 (61,18%) were people with Dm², in 42 (24,7%) people transient hyperglycemia were detected and 24 (14,1%) people were without any carbohydrate disturbances. Interestingly, in patients with AMI we can see wide fluctuations of blood glycemia level. We divided patients according to glycemia fluctuation during the day: between 4 and 11 Mmol/las normoglycemia, higher than 11 Mmol/las a hyperglycemia and if blood sugar level less than 4 Mmol/lwere defined as hypoglycemia. Hyperglycemia episodes (24.86%) were 10 times frequent than hypoglycemia (2.16%). All patients blood sugar were tightly controlled during the day and if needed they were received hypoglycemic treatment according to blood glycemia level. Early in-hospital death rate were among prospective study groups were more less than in retrospective patients 2.9% vs 10.9%. HbA1c level in patients after 3 months were in acceptable range in 66% of Dm² group and 88% of transient hyperglycemia group and remain high in 33% of Dm² and 11% of transient hyperglycemia group and suggested about inportance of tight glycemic control in that patients.

Conclusion: Hyperglycemia were frequent future in patients with AMI and presented in 85.88% cases, 61.18% were patients with Dm² and 24.7% with transient hyperglycemia. Hyperglycemia episodes were 10 times higher than hypoglycemia. Intensive control of blood glycemia with appropriate hypoglycemia measurements help to reduce in-hospital mortality rate.