Endocrine Abstracts

JOINT2881

Psoriatic arthritis may be accompanied by psoriasis and is known to be associated with metabolic syndrome and obesity. Diabetes mellitus type 2 may also be observed. Psoriatic arthritis and psoriasis are currently successfully managed by the administration of biological agents. Obesity may necessitate dose modification in the case of treatment with biological agents. Additionally, psoriatic arthritis may lead to mobility limitation. Obesity may further limit mobility. Therefore, the successful management of obesity in patients with psoriatic arthritis is critical. The aim was to present a cohort of patients suffering from psoriatic arthritis, florid psoriasis, metabolic syndrome and obesity who were successfully managed by the administration of GLP-1 receptor agonists. A cohort of 6 patients, 2 female and 4 male, suffering from psoriatic arthritis and florid psoriasis, aged 38-56 years, is presented. Patients had overt metabolic syndrome with obesity and diabetes mellitus type 2. All patients received metformin when entering the study. GLP-1 receptor agonists were administered to these patients for a period of 6 months. The administration of GLP-1 receptor agonists to this group of patients suffering from psoriatic arthritis, florid psoriasis and obesity led to weight loss of 1.2 – 8.2 kg. In addition, psoriasis lesions improved. Blood glucose levels also improved. GLP-1 receptor agonists were subsequently administered for 6 more months to all patients. No significant adverse events were noted. In particular, the administration of GLP-1 receptor agonists in patients on treatment with biological agents seemed to improve quality of life. Obesity in the context of metabolic syndrome may complicate psoriatic arthritis and psoriasis. The successful management of obesity in these patients is critical as it improves mobility and prevents disability deterioration. GLP-1 receptor agonists appear ideal for the management of obesity and diabetes mellitus type 2 in patients with psoriatic arthritis.