Endocrine Abstracts

JOINT3332

Introduction: In patients with type 2 diabetes mellitus, an increase in arterial blood pressure usually contributes to the development of complications. In this paper, we will examine the effects of hyperglycemia and the renin-aldosterone system on renal dysfunction, as well as the impact of arterial blood pressure correction on quality of life. Aim: To study the relationship between renin and aldosterone with the course and complications of the disease in patients with type 2 diabetes mellitus.

Materials and Methods: Patients diagnosed with type 2 diabetes mellitus at the Republican Specialised Scientific Practical Medical Center of Endocrinology during 2022-2024 were included in the study. Among them, 51.25% were women, and 48.75% were men. The average age of male patients was 48.6±2.54, and the average age of female patients was 53.41±1.65. Normal arterial blood pressure was detected in 23 (28.75%) of them (NBP), while high arterial blood pressure was detected in 57 (71.25%) patients (HTN).

Results: The duration of the disease was found to be 5.5±0.54 in patients with normal arterial blood pressure and 9.8±0.5 (P = 2.818) in patients with high arterial blood pressure. HbA1C was found to be 10.89±0.40 in NBP and 12±0.4 (P = 2) in HTN. VLDL cholesterol was 1.08±0.1 in NBP and 1.2±0.06 (P = 3.226) in HTN. HDL cholesterol was 2.2±0.23 in NBP and 1.4±0.12 (P = 3.314) in HTN. Renin was found to be 0.54±0.11 in NBP and 0.54±0.1 (P = 12.635) in HTN. Aldosterone was 0.92±0.06 in NBP and 0.9±0.04 (P = 2.095) in HTN. When patients compared by disease duration Renin aldosterone ratio were decreased probably due to Diabetic Nephropathy.

Conclusions: In patients with type 2 diabetes mellitus, renin and angiotensin were found to be high relative to arterial blood pressure. It was determined that as the duration of the disease increased, these indicators decreased, which was related to the functional state of the kidneys.