Metabolic syndrome and cancer metabolic syndrome and cancer

Salah Dhoha Ben; Oumaima Dimassi; Khouloud Boujelben; Nada Hassairi; Kacem Akid Faten Haj; Nadia Charfi; Mouna Mnif; Mohamed Abid; Mouna Elleuch; Majdoub Nabila Rekik

doi:10.1530/endoabs.110.EP990

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Endocrine Abstracts (2025) 110 EP990 | DOI: 10.1530/endoabs.110.EP990

ECEESPE2025 ePoster Presentations Metabolism, Nutrition and Obesity (164 abstracts)

Metabolic syndrome and cancer metabolic syndrome and cancer

Dhoha Ben Salah ¹ , Oumaima Dimassi ¹ , Khouloud Boujelben ¹ , Nada Hassairi ¹ , Faten Haj Kacem Akid ¹ , Nadia Charfi ¹ , Mouna Mnif ¹ , Mohamed Abid ¹ , Mouna Elleuch ¹ & Nabila Rekik Majdoub ¹

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¹Department of Endocrinology Hedi Chaker Hospital, Sfax, Tunisia

JOINT2489

Introduction: Cancer is currently one of the leading causes of mortality worldwide. The aim of our study was to describe the epidemiological and clinical profile of cancer in patients with metabolic syndrome.

Methods: This was a retrospective study that included 16 patients with metabolic syndrome and cancer, collected between 2012 and 2021 in the Endocrinology Department of Sfax.

Results: Our study included 16 patients with a sex ratio of 0.45. The mean age at cancer diagnosis was 58.8 ± 14.8 years (range: 28–82). None of the patients had a family history of cancer. Hypertension was present in 81.3% of cases, diabetes in 62.5%, and established cardiovascular disease in 12.5%. The mean BMI was 29.25 ± 7.4 kg/m² (range: 20.48–54), with obesity found in 31.3% of patients. Android obesity was present in 81.8% of women vs only 20% of men. The mean systolic blood pressure was 139 ± 22.52 mmHg (range: 120–190), and the mean diastolic blood pressure was 82 ± 12.9 mmHg (range: 60–110). Mean fasting blood glucose was 12.23 mmol/l, mean HDL cholesterol was 0.97 ± 0.34 mmol/l, and mean triglycerides were 2.03 ± 1.13 mmol/L. Among the 16 patients: 6 had breast cancer, 2 prostate cancer,2 adrenocortical carcinoma, lung cancer, 1 renal cancer, 1testicular cancer, 1 thyroid cancer, 1 colorectal cancer and 1 lymphoma.

Discussion: The pathophysiological link between cancer and metabolic syndrome remains poorly understood. However, some studies implicate excessive caloric intake as a trigger for reactive oxygen species, which exert mutagenic effects.