Endocrine Abstracts

Preserving and restoring beta cell function is a key objective in efforts to modify the progression of type 1 diabetes (T1D). This Meet the Expert session will feature a leading expert who will discuss the latest advances in beta cell preservation, regeneration, and replacement therapies. Given the autoimmune nature of T1D, strategies aimed at protecting residual beta cells from immune attack remain crucial. Additionally, regenerative approaches seek to enhance beta cell survival and proliferation through small molecules, gene editing, and reprogramming strategies. Recent progress in stem cell-derived beta-like cells and islet transplantation offers potential solutions for restoring insulin production. Advances in encapsulation technologies and immune evasion strategies aim to improve the long-term survival and function of transplanted cells. Despite these promising developments, challenges remain, including immune rejection, the need for lifelong immunosuppression, and the difficulty of achieving full functional integration of beta cells. In this session, the expert will provide insights into current research, clinical applications, and the future of beta cell-directed therapies in T1D. Attendees will have the opportunity to engage in discussions on the most promising approaches and ongoing clinical trials, as well as the challenges that must be addressed to achieve durable beta cell function and a potential cure for T1D.