ECEESPE2025 Poster Presentations Reproductive and Developmental Endocrinology (93 abstracts)
Exposure to high anti-müllerian hormone (AMH) levels during mini-puberty in mice induces polycystic ovary syndrome-like defects in both sexes
Cotellessa Ludovica 1 , Veronica Sobrino 2 , Manuel Tena-Sempere 2 , Natalia Lima 3 , Ruben Nogueiras 3 , Mauro Silva 4 & Paolo Giacobini 1
1inserm U1172, Univ. Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition, UMR-S 1172, Lille, France, Lille, France; 2Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Cordoba, Spain, Cordoba, Spain; 3CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Spain, Santiago de compostela, Spain; 4University of Laval, Laval, Canada
JOINT1330
Polycystic Ovary Syndrome (PCOS) is the most common endocrinopathy affecting women worldwide, leading to various long-term cardio-metabolic repercussions. Despite its significant impact, there is currently no cure, emphasizing the urgent need for effective treatments. Gestational excess of androgens and anti-Müllerian hormone (AMH) is common in women with PCOS and preclinical studies have demonstrated that abnormal exposure to these hormones during prenatal development can cause PCOS-like traits in adult female offspring. However, it is unclear if there is also a critical period of susceptibility to PCOS during early postnatal life. Interestingly, AMH levels have been found to be significantly higher during mini-puberty in both daughters and sons of mothers with PCOS compared to infants of non-PCOS women. To elucidate whether elevated AMH levels during infancy in offspring of women with PCOS are a byproduct or a driving force behind the condition, we developed an innovative mouse model by exposing otherwise healthy mice to AMH during mini-puberty. We showed that such treatment induced PCOS-like reproductive and metabolic defects in females and males alike. Additionally, we developed a pharmacological approach that showed beneficial effects on both reproductive and metabolic PCOS-related defects. These findings suggest that exposure to elevated serum AMH levels during mini-puberty plays a causal role in the pathophysiology of PCOS. They also identify a window of opportunity for developing novel therapeutic preventive strategies for PCOS.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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