ECEESPE2025 Poster Presentations Reproductive and Developmental Endocrinology (93 abstracts)
PCOS in adolescent girls vs young women: similar distribution of body fat, different severity of PCOS phenotype
Cristina Garcia-Beltran 1 , Marianne Andersen 2 , Firdevs Bas 3 , Judit Bassols 4 , Feyza Darendeliler 3 , Flaminia Fanelli 5 , Elke Fröhlich-Reiterer 6 , Alessandra Gambineri 5 , Dorte Glintborg 2 , Abel Lopez-Bermejo 7 , Silvia Marin 1 , Barbara Obermayer-Pietsch 6 , Rønnaug Ødegård 8 , Pernille Ravn 2 , Cristina Salvador 1 , Eszter Vanky 8 , Melek Yildiz 3 , Francis de Zegher 9 & Lourdes Ibañez 1,10
1Hospital Sant Joan de Deu, Barcelona, Spain; 2Odense University Hospital, Odense, Denmark; 3Istanbul University Hospital, Istanbul, Türkiye; 4Girona Institute for Biomedical Research (IDIBGI), Girona, Spain; 5S. Orsola-Hospital, Bologna, Italy; 6Medical University of Graz, Graz, Austria; 7Dr. Josep Trueta Hospital & Girona Institute for Biomedical Research (IDIBGI), Girona, Spain; 8St. Olavs Hospital, Trondheim, Norway; 9Leuven Research & Development, University of Leuven, Leuven, Belgium; 10CIBERDEM, Instituto de Salud Carlos III, Madrid, Spain
JOINT752
In essence, polycystic ovary syndrome (PCOS) is an endocrine-metabolic mode driven by ectopic fat [1]. It is unknown whether similar degrees of total, truncal, abdominal, visceral and hepatic adiposity associate to similar PCOS phenotypes in adolescent girls vs young women. The baseline data of an international PCOS intervention study [2] (www.spiomet4health.eu; Horizon 2020 grant 899671) offered an unanticipated opportunity to answer this question. Indeed, adolescent girls with PCOS (n = 129; mean ± SD; 16 ± 2 yr) and young women with PCOS (n = 183; 22 ± 1 yr) in this study happened to have similar measures of body adiposity: BMI 27 ± 5 vs 27 ± 5 kg/m2; total fat (by DXA) 29 ± 11 vs 28 ± 11 kg; truncal fat (by DXA) 14 ± 6 vs 13 ± 6 kg; non-truncal fat (by DXA) 15 ± 5 vs 15 ± 6 kg; abdominal thickness of subcutaneous fat (by MRI) 6 ± 2 vs 6 ± 2 cm; abdominal area of subcutaneous fat (by MRI) 218 ± 77 vs 219 ± 84 cm2; visceral fat (by MRI) 48 ± 29 vs 52 ± 34 cm2; and hepatic fat (by MRI-PDFF) 7 ± 5 vs 7 ± 2 %. However, the PCOS phenotype was more severe (all P < 0.001) in adolescent girls than in young women: hirsutism score (modified Ferriman-Gallwey) 13 ± 6 vs 10 ± 6; SHBG 32 ± 18 vs 41 ± 20 nmol/l; free androgen index 6.8 ± 4.6 vs 4.9 ± 3.0; HOMA-IR 3.3 ± 3.2 vs 2.3 ± 2.5; mean serum insulin during oGTT 437 ± 456 vs 253 ± 218 pmol/l; HDL-cholesterol 1.3 ± 0.3 vs 1.6 ± 0.4 mmol/l. In conclusion, the baseline data of an intervention study disclosed unexpectedly that a similar fat distribution associates with a more severe PCOS phenotype in adolescent girls than in young women. A differential secretion of growth hormone may be among the mechanisms underpinning the difference in PCOS phenotype [3,4]. In order to reverse PCOS, measures to reduce adiposity and/or to redistribute fat may thus be even more relevant for adolescent girls than for young women.
References1. Ibáñez L, de Zegher F. Trends Mol Med. 2023; 29:354-363. 2. Garcia-Beltran C, et al. Trials. 2023; 24:589. 3. Morales AJ, et al. J Clin Endocrinol Metab. 1996; 81:2854-64. 4. Ibáñez L, et al. J Pediatr. 2004; 144:23-9.
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