ECEESPE2025 Poster Presentations Reproductive and Developmental Endocrinology (93 abstracts)
The impact of estrogens on gut microbiome in post-menopause and premature ovarian insufficiency - a meta-analysis and systematic review
Kristina Saravinovska 1,2 , Daniele Santi 3 , Francesco Costantino 3 , Antoan Stefan Sojat 1 , Giorgia Spaggiari 4 , Miomira Ivovic 1,2 , Irene Lambrinoudaki 5 , Elena Armeni 5,6 , Svetlana Vujovic 1,2 & Ljiljana Marina 1,2
1Clinic of Endocrinology, Diabetes and Metabolic Diseases, University Clinical Centre of Serbia, National Centre for Infertility and Endocrinology of Gender, Belgrade, Serbia; 2Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 3Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; 4Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy; 52nd Department of Obstetrics and Gynaecology, University of Athens, Aretaieio Hospital, Athens, Greece; 6Royal Free Hospital NHS Trust, London, United Kingdom
JOINT3323
Objectives: There has been a rising interest in the relationship between gut microbiome (GM) changes and women’s reproductive health, with estrobolome taking a central role in the interplay. This meta-analysis aimed to systematically review and combine existing data to assess GM alterations in postmenopausal and women with premature ovarian insufficiency (POI) - hypoestrogenic women when compared to premenopausal (euestrogenic) women.
Design and methods: Medline, EMBASE and Cochrane Library were searched for relevant articles and selected according to the strict inclusion criteria. Studies comparing euestrogenic (premenopausal) to hypoestrogenic (POI or postmenopausal) women were considered. The inclusion criteria were: no use of hormonal replacement therapy (HRT) or hormonal contraceptives, no active infections, no active intestinal diseases and no actual history of cancer of any origin. Seven of 15 papers assessed for eligibility were included in the analysis, incorporating data from 1730 participants. The risk of bias was assessed using the Newcastle-Ottawa scale. This study was registered on the International Prospective Register of Systematic Reviews (PROSPERO), CRD42024497630.
Results: No statistically significant differences were observed in α–diversity (P = 0.990), Bacteroidetes (B) (P = 0.440), or Firmicutes (F) abundance (P = 0.110) between hypoestrogenic and euestrogenic groups. Similarly, the B/F ratio (P = 0.400) showed no significant difference between the groups. However, the results were highly heterogeneous in the current literature, with I2 scores ranging from 68% to 99%.
Conclusion: This meta-analysis showed no differences in GM composition between postmenopausal and premenopausal women, nor between women with POI and premenopausal women. These findings should be interpreted with caution due to the high heterogeneity of the populations studied. Future research prioritizing the exclusion of already known GM disruptors is critical for women with POI and postmenopausal women. This meta-analysis challenges the assumed link between estrogen levels and GM alterations while stressing the need for rigorous, high-quality research to elucidate GM characteristics in estrogen-dependent states.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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