Endocrine Abstracts

JOINT3620

Background and Objectives: Thyoid abnormalities were regarded common in McCune-Albright syndrome(MAS), however, thyroid nudular may be more than abnormalites of thyroid function. The aim of this study is to detect the prevalence of thyroid nudular in girls who was diagnosed MAS and had GnRH independent precocious puberty as the initiation manifestation.

Methods: From 2019 to 2024, 65 girls who had the precocious puberty as the first manifestation and were diagnosed MAS, as well as had thyroid ultrasoud inspection were enrolled in our study, the prevalence of thyroid nudules was analysed and was compared with 89 normal girls.

Results: The age of onset of precocious puberty was 3.44±2.03 years old, and the age at thyroid ultrasound detction was 10.91±5.66 years. In this 65 girls, 29 (44.6%) were found thyroid nudular, while in normal girls, only 15 (16.9%) were detected thyroid nudular, and the difference was significant(P < 0.001). In MAS grils with thyroid nudules, 17 were nodular goiter (58.6%), the others were follicular cyst (37.9%) and diffuse goiter (3.4%).18 cases (62.0%) were bilateral, while 11 (37.9%)were unilateral. In whom, only 2 had hyperthyroidism, and the other 2 had hypothyroidism. Anti-thyroid antibodies were negtive in all girls. 21 girls Ti-RADS grade were less than 3, 7 were grade 3 and only 1 was grade 4. Duration of follow-up was 0.5-6 years, and fine-needle aspiration biopsy was performed in 2 patients, however, no malignancy were found.

Conclusion: In girls with MAS and has precocious puberty concurrently, abnormalities of thyroid ultrasound dection were more prevalent than prevalence of hyperthyroidism or hypothyroidism. In addition to evaluatiion of thyroid function, thyroid ultrasound examination should also be considered and the follow-up of thyroid nudular is recommended.

Key words: thyroid, McCune Albright syndrome, GNAS gene, precocious puberty,.