The relationship between TSH suppression and metabolic associated fatty liver disease (MAFLD) in patients with thyroid cancer

Ruveyda Bulut; Afruz Babayeva; Mahinur Cerit; Halit Şendur; Cerit Ethem Turgay; Altinova Alev; Mujde Akturk; Fusun Toruner; Ayhan Karakoc; Yalcin Mehmet Muhittin

doi:10.1530/endoabs.110.P1219

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Endocrine Abstracts (2025) 110 P1219 | DOI: 10.1530/endoabs.110.P1219

ECEESPE2025 Poster Presentations Thyroid (141 abstracts)

The relationship between TSH suppression and metabolic associated fatty liver disease (MAFLD) in patients with thyroid cancer

Rüveyda Bulut ¹ , Afruz Babayeva ² , Mahinur Cerit ³ , Halit Şendur ³ , Ethem Turgay Cerit ² , Altinova Alev ² , Mujde Akturk ² , Fusun Toruner ² , Ayhan Karakoc ² & Mehmet Muhittin Yalcin ²

Author affiliations

¹Gazi University Faculty of Medicine Department of Internal Medicine, Ankara, Türkiye; ²Gazi University Faculty of Medicine Department of Endocrinology and Metabolism, Ankara, Türkiye; ³Gazi University Faculty of Medicine Department of Radiology, Ankara, Türkiye

JOINT2134

Metabolic associated fatty liver disease (MAFLD) is a clinical spectrum ranging from simple steatosis to cirrhosis and hepatocellular carcinoma (HCC) with increasing prevalence worldwide. Although its close relationship with obesity, metabolic syndrome and diabetes is known, its mortality and morbidity are high. Thyroid hormones play a regulatory role in cell metabolism and are effective on metabolic parameters involved in the etiology of MAFLD. Although the studies conducted so far mostly support that hypothyroidism increases the risk of MAFLD, there are not enough studies investigating the effect of hyperthyroidism on MAFLD. The aim of this study was to investigate the effect of subclinical thyrotoxicosis on MAFLD.

Patients and methods: Between March 2023 and November 2023, 38 patients with subclinical thyrotoxicosis who were followed up due to thyroid cancer in remission and who applied to Gazi University Medical Faculty, Endocrinology Clinic between March 2023 and November 2023 were included in the study and 38 healthy people with similar age and gender distribution were included in the control group. 76 people were included in the study. Liver function tests, serum lipid levels, TNF-alpha, IL-6, T4, TSH tests were analysed. Quantitative measurement was performed by ultrasonography for fatty liver disease and TAI was calculated and the stage of hepatic steatosis was measured and recorded as grade. Fatty liver index(FLI) was calculated.

Results: We found no significant difference between the subclinical thyrotoxicosis group and the euthyroid group in terms of MAFLD diagnosed by imaging. In both groups, we found a significant correlation between the grade of hepatic steatosis and age, BMI, waist circumference, ALT, GGT, LDL and TG levels. In analyses controlling for age and body mass index (BMI), we found a significant, positive correlation between TSH and the grade of hepatic steatosis.

Discussion: We found a negative correlation between TSH suppression level and MAFLD, and our results are consistent with the literature in this respect. Addition to B-mode ultrasound for the diagnosis of MAFLD, we preferred TAI measurements because of its sensitivity, which have not been used in a similar study before.