Endocrine Abstracts

JOINT3806

Objective: The objective is to evaluate the quality of life in patients with gradual-onset adrenal insufficiency and assess its overall impact.

Materials and patients: This is a descriptive study conducted in our department, using the AddiQOL questionnaire, involving 48 patients with adrenal insufficiency who experienced episodes of acute decompensation between January 2022 and December 2024.

Results: Our study included 48 patients, of which 17 were men and 31 were women. The average age was 37 years, with 40% being patients with Addison’s disease. Overall health-related quality of life was impaired in 73% of cases, while physical, social, and emotional health were affected in 93%, 82%, and 75% of cases, respectively. The most common symptoms were fatigue (100% of cases), abdominal pain (83%), nausea and vomiting (41%), loss of appetite (75%), insomnia (66%), constipation (33%), and diarrhea (25%).

Conclusion: The impairment of quality of life in patients with adrenal insufficiency remains significant, with a variety of symptoms, the most common being fatigue, which persists despite substitution therapy.