ECEESPE2025 Poster Presentations Bone and Mineral Metabolism (112 abstracts)
Insufficient bone mineralization to sustain mechanical load of weight in obese girls: a cross-sectional study
Chloe Ramandason 1 , Regis Coutant 2 , Amsellemn Jager Jessica 2 , Bouhours-Nouet Natacha 2 , Donzeau Aurelie 2 , Rouleau Stephanie 2 , Labarre Emmanuelle 2 & Levaillant Lucie 2
1University Hospital, Tours, France; 2University Hospital, Angers, France
JOINT3344
Context: Despite an apparent increase in bone mineral content (BMC) and bone mineral density (BMD) in obese compared to lean children, the fracture risk is higher. On the one hand, mineralization measurements by dual-energy X-ray absorptiometry (DXA) may be falsely raised by the increase in height and width in obese children. On the other hand, the rise in BMC and BMD measured by DXA may not sustain the mechanical load associated with weight.
Objective: We described bone mineralization in overweight/obese girls and lean girls in relation to body composition.
Methods: This was a cross-sectional study in the Pediatric Endocrinology Unit of Angers University Hospital. Three hundred and twenty-eight overweight/obese girls aged 7-18 underwent DXA measurements. Using the same DXA model, their bone mineralization was compared with data from 441 lean girls of similar age and height from the NHANES 2011-2015 studies.
Results: The mean age- and height-adjusted difference in total-body-less-head BMC (TBLH BMC) between obese and lean girls was 186 ± 11 g (P <. 001). Each 1 kg/m2 increase in body mass index (BMI) was associated with a gain of +21 ± 2 g of TBLH BMC in lean girls vs +19 ± 1 g in obese girls (P <. 05 for the difference). Each 1 kg/m2 increase in lean BMI (LBMI) was associated with a gain of +63 ± 4 g of TBLH BMC with no difference between lean and obese girls, whereas fat mass index (FMI) did not have a significant effect on TBLH BMC.
Conclusion: The increase in bone mineralization in obese girls does not adapt to the rise in body mass.
Keywords: obese, girls, bone mineral content, mechanical load, lean mass, fat mass
Volume 110
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2025 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more