Endocrine Abstracts

JOINT3330

Background: Type 1 diabetes mellitus (T1DM) is a complex metabolic condition marked by persistent hyperglycemia resulting from the autoimmune destruction of pancreatic β cells. Sleep is essential for sustaining the equilibrium of bodily functioning. A recent study indicates that sleep modification influences several physiological systems, including metabolic and endocrine control. A sufficient sleep is needed for optimum growth and development in children. Poor sleep in children with T1DM can lead to decreased insulin sensitivity and impair glycaemic control. High blood glucose level in uncontrolled diabetes can disrupt the normal production of growth hormones, leading to growth failure. The Asia-Pacific agreement advises 9–11 hours of sleep for children aged 9 to 13 years and 8–10 hours for those aged 14 to 18 years. The aim of this study is to analyse the correlation between sleep duration, HbA1c, and growth in children with T1DM

Methods: 37 T1DM Children who had been diagnosed with diabetes for > 6 months and had regular visits at the paediatric endocrinology outpatient clinic at Dr. Soetomo Hospital were included. Sleep duration was obtained from the average of self-reported sleep duration in the last weeks. Weight measurements were performed using a GEA Medical® digital scale, offering precision to within 100 grams. Height measurements were obtained using a Onemed® microtoise or stadiometer, assuring accuracy to the closest 1. 0 millimetre. Height and weight was transformed into z-scores standard deviations (SDS) according to the WHO growth chart. HbA1c data was taken from the most recent examination of the medical record. Spearman correlation test and St. Nicholas House Analysis (SNHA) in RStudio were used to process the data with p < 0. 05 considered significant.

Results: The mean age of the children is 158. 6 ± 45. 7 months old. The average HbA1c is 10 ± 2, and height SDS is -1. 389 ± 1. 28. The correlation test showed a significant correlation between sleep duration and HbA1c (rho= -0. 54; P < 0. 01), also a correlation between HbA1c and height SDS (rho= -0. 44, P < 0. 01), while there is a weak correlation between height SDS and sleep duration (rho=0. 25; P = 0. 1).

Conclusions: There is an association between sleep duration, growth, and HbA1c in children with T1DM. Children with less sleep duration have higher levels of HbA1c and lower height. Children with T1DM should have sufficient sleep to attain optimal glycaemic control, along with other established diabetic management like insulin administration, physical exercise, and dietary regulation.