Diurnal aldosterone and potassium intake in third trimester are associated with higher blood pressure in offspring up to 5 years of age

Hajir Al-Jorani; Richard C Jensen; Tina K Jensen; Henrik Thybo Christesen; Jan Stener Jorgensen; Lucas Bacmeister; Ralf Dechend; Dorte Glintborg; Boye L Jensen; Marianne S Andersen

doi:10.1530/endoabs.110.P66

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Endocrine Abstracts (2025) 110 P66 | DOI: 10.1530/endoabs.110.P66

ECEESPE2025 Poster Presentations Adrenal and Cardiovascular Endocrinology (169 abstracts)

Diurnal aldosterone and potassium intake in third trimester are associated with higher blood pressure in offspring up to 5 years of age

Hajir Al-Jorani ¹ , Richard C Jensen ^1,2 , Tina K Jensen ^2,3 , Henrik Thybo Christesen ³ , Jan Stener Jørgensen ³ , Lucas Bacmeister ⁴ , Ralf Dechend ⁵ , Dorte Glintborg ¹ , Boye L Jensen ⁶ & Marianne S Andersen ¹

Author affiliations

¹Department of Endocrinology, Odense University Hospital, Odense, Denmark, Odense, Denmark; ²Department of Clinical Pharmacology, Pharmacy and Environmental Medicine, University of Southern Denmark, Odense, Denmark, Odense, Denmark; ³Odense Child Cohort, Hans Christian Andersen Children’s Hospital, Odense University Hospital, Odense, Denmark, Odense, Denmark; ⁴Clinic for Cardiology and Angiology, University Heart Center Freiburg–Bad Krozingen, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Germany, Freiburg, Germany; ⁵Experimental and Clinical Research Center, a cooperation between the Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association and the Charité–Universitätsmedizin Berlin, Germany (R.D.). HELIOS Clinic Berlin-Buch, Department of Cardiology and Nephrology, Berlin, Germany (R.D.), Berlin, Germany; ⁶Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark, Odense, Denmark

JOINT372

Background: Offspring blood pressure (OBP) may be programmed during pregnancy. Accordingly, maternal third trimester 24-hour (24 h) urine (u-) aldosterone levels are associated with feto-placental trophic effects. Furthermore, high potassium and low sodium intakes are generally recommended in adults with normal renal function. We hypothesized that maternal 24 h u-aldosterone levels were positively associated with OBP and maternal intake of potassium and sodium may influence the association.

Objectives: To investigate associations between maternal third trimester 24 h u-aldosterone, potassium and sodium intakes and OBP.

Methods: In the prospective Odense Child Cohort, 475 mother–child dyads had 24 h u-aldosterone from gestational week 29 and OBP (systolic (SBP) and diastolic (DBP)), at ages 3 and 18 months and 3 and 5 years. Maternal potassium and sodium intakes were calculated from 24 h u-potassium and u-sodium excretions.

Results: Increased maternal 24 h u-aldosterone associated with higher SBP in offspring at ages 3 months (β=0.54 mmHg (95% CI: 0.29; 0.79)) and 18 months (β=0.24 mmHg (95% CI: 0.03; 0.44)). One thousand mg/day increase in maternal potassium intake was associated with an average increase in offspring SBP of 0.68 mmHg (95% CI: 0.02; 1.34) up to 5 years of age (pooled), with significant associations only in girls (β=1.14 mmHg (95% CI: 0.21; 2.08)). No significant association was seen between maternal sodium intake and OBP.

Conclusions: Elevated maternal 24 h u-aldosterone and higher dietary potassium intake were associated with higher OBP, but within normal range, in young children, and girls were more susceptible to maternal potassium intake.