Endocrine Abstracts

JOINT2688

Objectives: Non-high-density lipoprotein (HDL) cholesterol is an alternative method to assess dyslipidemia and is not required fasting. We aimed to assess the usefulness of non-HDL cholesterol for screening dyslipidemia in overweight Korean children.

Subjects and Methods: Total 751 overweight children and adolescents aged 2 to 20 years (268 boys and 483 girls). They were sampled lipid profile without fasting. Dyslipidemia was defined by having one of the followings; total cholesterol ≥200 mg/dL, triglyceride ≥100 mg/dL or ≥130 mg/dL depending on age, low-density lipoprotein (LDL) cholesterol ≥130 mg/dL, or HDL cholesterol <40 mg/dL. Non-HDL cholesterol ≥145 mg/dL was used to detect dyslipidemia. After then, we compared the sensitivity of non-HDL cholesterol to those from the Korean National Health and Nutrition Examination Surveys which was taken at fasting state.

Results: The overall prevalence of dyslipidemia was 52.6%. The prevalence of non-HDL cholesterol level ≥145 mg/dL were 18.7% and 17.0% in boys and girls, respectively. Dyslipidemia was found in 94.0% and 85.4% of overweight boys and girls with high non-HDL level, respectively. High non-HDL cholesterol level especially detected high measured LDL-cholesterol level with a sensitivity of 100%, and a specificity of 92.0%, and a sensitivity of 97.8%, and a specificity of 91.3%, in boys and girls (P<0.001 and P<0.001, respectively). The Sensitivity of detecting high LDL-cholesterol level was higher in using randomly sampled non-HDL cholesterol compared to using fasting non-HDL cholesterol in boys and girls (11.6% vs. 7.3%, P=0.024 and 9.1% vs. 8.2%, P=0.253, respectively).

Conclusions: Non-HDL cholesterol at random samples appeared to be useful in screening dyslipidemia in overweight children and adolescents. It was easily calculated from random sample not required fasting.