Endocrine Abstracts

JOINT2947

Method: From 2011 to 2022, children who were diagnosed CPP or EFP in our center and had completion of cranial magnetic resonance imaging(MRI) were studied. 1087 children were enrolled, including 908 girls (668 CPP, 240 EFP) and 179 boys (89 CPP, 90 EFP), and divided into 3 groups depending on the detection and the types of intracranial lesions. Group 1: no intracranial lesion, Group 2: confirmed hypothalamic hamartoma and glioma, and Group 3: other intracranial lesions. The age of puberty onset, serum levels of FSH, LH, bone age (BA), and Z score of height for BA (SDSBA) at the diagnosis were analyzed.

Results: In girls, 132 cases be found intracranial lesions (14.5%). In boys, 35 be found intracranial lesions (19.6%), with no difference from girls (P = 0.089).33.7% (17 in Group 2) Girls<6 years old be found intracranial lesions, higher than that≥6 years old, the latter was 12.1% (only 2 in Group 2)(P<0.001). Boys<7 years old also had increased incidence of intracranial lesions than that ≥7 years old: 53.8% (5 cases in Group 2) vs 16.9% only 1 in Group 2) (P = 0.004). No difference of incidence of brain lesions in girls with CPP and EFP (15.3% vs 12.5%, P = 0.296), as well as in boys(22.5%, 16.7%, P = 0.432). Group 2 had earliest onset of puberty (average age was 1.9 years for girls, 1.0 years for boys), but no difference of acceleration of bone age and height SDSBA were found at diagnosis when compared with group1 and group3 (P >0.05). puberty No diference was found of the age of onset of puberty, baseline LH and FSH, LH peak after stimulation, aceleration of BA as well as height SDSBA between group1 and group3 (P >0.05).

Conclusion: hypothalamic hamartoma and glioma are more common in children with CPP, especially in girls under the age of 6 or boys under the age of 7. In girls above the age of 6, and boys above 7 years old, suffered from CPP or EFP, incidence of intracranial lesions was lower than expected, and most are Incidental lesions, and have little relevence with the process of puberty.