Endocrine Abstracts

Background: Pancreatic neuroendocrine tumours (PanNET) are rare but with increasing incidence. Surgical resection is the only potentially curative therapy for localized disease. Criteria for selection for surgery vary across different healthcare systems. This population-based study aimed to study the demographic and clinical characteristics of resected vs non-resected PanNET in NCRAS and SEER.

Methods: A total of 3,612 and 8,322 patients with PanNET were extracted from NCRAS (2012-2021) and SEER (2011-2022) databases respectively. Descriptive summary statistics were calculated for both cohorts stratified by receiving surgical resection. Statistical hypothesis tests were used to compare patients who did not receive resection (Group-1) and those who did (Group-2).

Results: In NCRAS, median age was 64-years. Most patients were males (54.3%), white (86.1%), living in urban areas (76.6%), had median size of 25 mm, T1 stage (22.6%), N0 stage (43.5%), M0 stage (45%), and Stage-group 4 (26.7%). Group-2 represented 43.2%. The most common procedures were partial pancreatectomy/Whipple resection (88.9%). Group-2 was characterized by being of younger age, male sex, less advanced T-stage, N-stage, M-stage, and stage-group. In SEER, median age was 63-years. Most patients were males (55.0%), white (64.7%), living in metropolitan areas (90.6%), had median size of 24 mm, N0 stage (73.7%), M0 stage (78.4%), and Stage 1 (42.4%). Group-2 represented 59.0%. The most common procedures were partial pancreatectomy/Whipple resection (80.8%). Group-2 was characterized by being of younger age, male sex, smaller size, less advanced M-stage, stage-group, receiving less radiotherapy and chemotherapy.

Conclusion: NCRAS and SEER cohorts had similar demographic and clinical characteristics of PanNET. However, NCRAS had less stage-group 1, more stage-group 4 cases, and fewer resections when compared to SEER. This difference in resection rates is likely due to difference in stage at diagnosis and differences in healthcare systems. The most common resection was partial pancreatectomy/Whipple resection in both cohorts. Receiving surgery was associated with younger age, male sex, less advanced M-stage, stage-group in both cohorts.