Audit on cardiovascular risk assessment in a cohort of adults with Adrenal Insufficiency

T Dunleavy; A Ambreen; A Nawaz Khan; B Fleming; A Khattak; M Mustafa Jaffar; T Ahern; J Ioana

doi:10.1530/endoabs.115.EP60

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Endocrine Abstracts (2026) 115 EP60 | DOI: 10.1530/endoabs.115.EP60

IES2025 Research, Audit and Quality Improvement Projects E-Posters (60 abstracts)

Audit on cardiovascular risk assessment in a cohort of adults with Adrenal Insufficiency

T Dunleavy* , A. Ambreen* , A Nawaz Khan , B Fleming , A Khattak , M Mustafa Jaffar , T Ahern & J Ioana

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Department of Endocrinology, Our Lady of Lourdes, Drogheda, Ireland *Joint first authors

Adrenal Insufficiency (AI) is associated with increased cardiovascular risk factors (CVR). There is no optimal glucocorticoid replacement regime and excess of cortisol can lead to detrimental metabolic effects. Data extracted from one-year-adrenal clinic letters included twenty AI patients, 17 (85%) with primary-AI and rest with secondary-AI. The average age was 51 (±20) years old, BMI 22(±3) kg/m² and 9 (45%) were male.7 (35%) had past medical history of hypertension, 1 had a stroke, 2 had Atrial fibrillation, 3 had Diabetes. The mean hydrocortisone dose-equivalent was 0.24 (±0.04) mg/Kg or 16(±3 ) mg/day and 100 mg Fludrocortisone/day. 19 (95%) patients had a documented blood pressure, average systolic / diastolic being 124 (±17) / 72(±10) mm Hg. Out of the 15 (75%) patients who had HbA1c checked, the mean was 36.8 (±6.37) mmol/l/mol. 11 (55%) had lipid profile documented with average of T-Cho 5 (±1), HDL 1.3 (±0.2), LDL 3 (±1), Tg 1.1 (±0.6). Only 4 (20%) patients were on cholesterol-lowering agents. Overall, findings suggest that the steroid dose is similar to the one used in current literature, but CVR are sometimes left unmonitored. Our study aims to emphasize the need for a comprehensive approach including regular cardiovascular risk assessment in patients with adrenal insufficiency.