IES2025 Research, Audit and Quality Improvement Projects Physical Posters (55 abstracts)
Clinical Outcomes of Advanced Hybrid Closed-Loop (AHCL) Therapy in Adults with Type 1 Diabetes: Implementation in a Regional Centre
Arsalan Qureshi 1,2 , Hafiz Muhammad Sohail 1 , Georgina Doyle 1 , Lorraine Kelly 1 , Michelle McCormack 1 , Catherine McGarry 1 , Ciara O’Brien 1 , Liam Óg Delaney 1 , Jayant Sharma 1 & Ma Pyeh Kyithar 1,3
1Diabetes & Endocrinology Department, Midland Regional Hospital Portlaoise, Ireland; 2College of Physicians and Surgeons Pakistan; 3School of Medicine, Trinity College Dublin, Ireland
Introduction: Randomized trials and real-world evidence have demonstrated that advanced hybrid closed-loop (AHCL) insulin delivery systems improve glycaemic ranges and quality of life in people with type 1 diabetes (T1D). In autumn 2023, our diabetes centre launched an insulin pump service for adults with T1D. This study assessed glycaemic outcomes in adults with T1D using AHCL therapy within our service.
Methods: We performed a retrospective analysis of adults with T1D (age ≥16 years) who shared glycaemic data with our service up to July 2025. Data were obtained from Dexcom Clarity, Medtronic CareLink, and Ward Enquiry laboratory systems.
Results: Seventy adults with T1DM using AHCL systems were included (mean age 34.3±13.9 years; 46 females, 24 males). Prior to AHCL initiation, their glycaemic ranges were suboptimal with mean Time -in-Range (TIR) of 16.5±18.6 %, and mean HbA1c of 67.0±19.9 mmol/mol. Only 2.7 % of them achieved the recommended ≥70% TIR. Following AHCL initiation, mean TIR increased to 75±11.3 % with 63.5% of the cohort meeting ≥70% TIR. Mean glucose management indicator was 7.45 ± 1.53% .Mean HbA1c decreased to 55.44±10.6 mmol/mol (P = 0.0012 pre- vs. post-AHCL). By July 2025, the average duration on AHCL therapy was 17±7.2 months, with average SmartGuard usage of 91.2±12.9 %. All participants used the MiniMed™ 780G system.
Conclusion: Implementation of AHCL therapy in our regional diabetes service led to substantial improvements in glycaemic parameters among adults with T1D. Ongoing service-level data capture, coupled with sustained resource allocation, will support continuous quality improvement in T1D service.
Volume 115
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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